Title:
CERAMIDE DERIVATIVES AS MODULATORS OF IMMUNITY AND AUTOIMMUNITY
Document Type and Number:
Japanese Patent JP2015007125
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide ceramide derivatives as modulators of immunity and autoimmunity.SOLUTION: Provided are α-galactosyl ceramide and glycosyl ceramide (ceramide-like glycolipids) for modulating NK T cells. The ceramide-like glycolipids vary in cytokines induced in the NK T cells and vary in the antigen-presenting cells that can efficiently present a compound to the NK T cells. Provided is a pharmaceutical composition comprising ceramide-like glycolipids and dendritic cells. Also provided is a method for utilizing ceramide-like glycolipids as vaccine to activate NK T cells, to stimulate the immune system and to treat mammals. The invention also provides a method for evaluating a compound for its ability to activate NK T cells in the presence of cells expressing CD1d protein.
Inventors:
PORCELLI STEVEN A
Application Number:
JP2014185949A
Publication Date:
January 15, 2015
Filing Date:
September 12, 2014
Export Citation:
Assignee:
EINSTEIN COLL MED
International Classes:
C07H15/04; A61K31/7032; A61K31/715; A61K39/00; A61P1/16; A61P3/10; A61P7/04; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P21/04; A61P25/00; A61P29/00; A61P31/00; A61P35/00; A61P37/02; A61P37/06
Foreign References:
| WO2004028475A2 | 2004-04-08 |
Attorney, Agent or Firm:
Aoki 篤
Ishida 敬
Tsumoru Fukumoto
Tetsuji Koga
Yoichi Watanabe
Nakajima 勝
Ryotaro Takei
Ishida 敬
Tsumoru Fukumoto
Tetsuji Koga
Yoichi Watanabe
Nakajima 勝
Ryotaro Takei