NEW MATERIAL: Benzylcyclanone derivs. represented by formula I [R1 and R3 are each H, OH, an alkyl or an alkoxy, R3 and R4 are each H or OH (at least one of them is OH); R5-R8 are each H, an alkyl, an alalkyl or aryl; R5 and R6, and R7 and R8 form a saturated ring along with C of a ring to which they are bonded, X is O or -(CR9R10) (n is 1 or 2 and R9 and R10 are H or methyl)].
EXAMPLE: 3',4',5'-trihydroxy-4-benzyl-tetrahydro-2,2,5,5-tetramethylfran-3-one.
USE: A treatment agent of inflammation and allergy of the skin.
PROCESS: For example, aromatic aldehyde represented by formula II (R1'-R4' are R1-R4) is reacted with a compd. represented by formula III in a solvent in the presence of alkali metal alcoholate within a temp. range from -78°C to the b.p. of the solvent to obtain benzylidenecyclanone represented by the formula IV and this compd. is reduced to obtain the compd. represented by the formula I.
ARAN RAGURANJI
JIERAARU RANGU
ANDORE DOUFURANDORU
BERUNADETSUTO RIYUPII
