Title:
ベンジルフェニルグルコピラノシド誘導体
Document Type and Number:
Japanese Patent JP4425318
Kind Code:
B2
Abstract:
The present invention relates to a benzylphenyl glucopyranoside derivative having an excellent inhibitory effect on human SGLT1 and/or SGLT2 activity. There is provided a compound or a pharmacologically acceptable salt thereof represented by the following general formula (I):
wherein
R 1 represents a hydrogen atom, an amino group, a hydroxy C 1 -C 6 alkyl group, etc.; R 2 represents a hydrogen atom, etc.; R 3 represents a C 1 -C 6 alkyl group, a hydroxy C 1 -C 6 alkyl group, etc.; R 4 represents a hydrogen atom, a C 2 -C 7 acyl group, etc.; R 5 , R 6 , R 7 , and R 8 are the same or different and each represents a hydrogen atom or a C 1 -C 6 alkyl group, provided that R 5 , R 6 , R 7 and R 8 are not hydrogen atoms at the same time; n is 0 to 4; and X is CH or N.
Inventors:
Honda
Small mouth
Masao Yoshida
Ryo Okuyama
Ogata Tsuneaki
Manabu Abe
Kenjiro Ueda
Jun Osumi
Izumi Masanori
Small mouth
Masao Yoshida
Ryo Okuyama
Ogata Tsuneaki
Manabu Abe
Kenjiro Ueda
Jun Osumi
Izumi Masanori
Application Number:
JP2008229193A
Publication Date:
March 03, 2010
Filing Date:
September 08, 2008
Export Citation:
Assignee:
Daiichi Sankyo Co., Ltd.
International Classes:
C07H15/203; A61K31/7034; A61K31/7036; A61K31/706; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P7/10; A61P9/10; A61P9/12; A61P13/12; A61P19/06; A61P25/00; A61P27/02; A61P27/12; A61P31/04; A61P43/00; C07H17/02
Foreign References:
| WO2005095429A1 | ||||
| WO2001068660A1 | ||||
| WO2002044192A1 | ||||
| WO2005095372A1 |
Attorney, Agent or Firm:
Kimiki Ishibashi
Toshiaki Yaguchi
Yuki Echigo
Toshiaki Yaguchi
Yuki Echigo