To obtain a new protein for inhibiting intracellular p27, lightening inhibition of cell proliferation caused by p27 protein, useful as a binding partner for an inhibitor of a cyclin-dependent kinase effective for diagnosing and treating tumor, etc.
This new protein inhibits intercellular protein p27, lightens inhibition of cell proliferation caused by p27 protein by the treatment, is useful for diagnosing and treating, tumor, etc., as a binder partner for cyclin-dependent kinase. The gene is useful for a nucleic acid construct for gene therapy, etc. The protein is obtained by preparing a cDNA library derived from a mouse fetus by using a strain transformed with a vector having the total coding sequence of rat p27 protein, analyzing a histidine nutrient demanding colony in the presence of aminotriazole and obtaining the protein as p163 protein being p27 protein partner from a colony not encoding D cyclin.
BUERGIN ANDREA
SEDLACEK HANS-HARALD
