Title:
エクジソン受容体複合体を通して外因性遺伝子の発現を調節するための生物学的利用能のあるジアシルヒドラジン・リガンド
Document Type and Number:
Japanese Patent JP5238159
Kind Code:
B2
Abstract:
The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
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Inventors:
Hohmann, Robert, Eugene
Porter, David, W.
Chortic, Orestes
Tice, Colin, M.
Carlson, Glenn, Richard
Andrew Mayer
Opie, Thomas, Earl.
Porter, David, W.
Chortic, Orestes
Tice, Colin, M.
Carlson, Glenn, Richard
Andrew Mayer
Opie, Thomas, Earl.
Application Number:
JP2006508884A
Publication Date:
July 17, 2013
Filing Date:
February 27, 2004
Export Citation:
Assignee:
Intrexon Corporation
International Classes:
C07C243/38; A61K31/166; A61K31/175; A61K31/222; A61K31/27; A61K31/353; A61K31/357; A61K31/4035; A61K31/415; A61K31/416; A61K31/4164; A61K31/44; A61K31/4433; A61K31/4965; A61K31/695; A61P43/00; C07C243/24; C07C251/08; C07C251/38; C07C255/66; C07C281/10; C07C281/14; C07C309/59; C07C317/44; C07C317/46; C07D209/42; C07D213/86; C07D231/14; C07D231/56; C07D235/08; C07D241/24; C07D311/58; C07D319/08; C07D319/18; C07D405/12; C12N
Domestic Patent References:
| JP5163266A | ||||
| JP2000037189A | ||||
| JP3141245A | ||||
| JP4178380A | ||||
| JP8301832A |
Foreign References:
| US6013836 | ||||
| US5530028 |
Other References:
Bioorganic & Medicinal Chemistry Letters,2003年,13(11),1883-1886
Proceedings of the National Academy of Sciences of the United States of America,2002年,99(23),14710-14715
Pest Management Science,2003年,59(1),25-35
Tetrahedron,1997年,53(12),4219-4230
Proceedings of the National Academy of Sciences of the United States of America,2002年,99(23),14710-14715
Pest Management Science,2003年,59(1),25-35
Tetrahedron,1997年,53(12),4219-4230
Attorney, Agent or Firm:
Yuichi Yamada
Masakazu Noda
Ikeda adult
Masakazu Noda
Ikeda adult
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