Title:
C70含有リポソームおよびその製造方法、並びにその利用
Document Type and Number:
Japanese Patent JP5334170
Kind Code:
B2
Abstract:
A solution containing a C 70 cyclodextrin complex and a solution containing a lipid that is capable of forming a liposome are mixed together at a temperature in a range of 10 °C to 45 °C. This produces a C 70 -incorporated liposome which keeps a physical property that the C 70 fullerene originally has, and is stably solubilized in a polar solvent. Hence, the present invention provides a C 70 -incorporated liposome which keeps a physical property that the C 70 fullerene originally has, and which is stably solubilized in a polar solvent, a production method of the same, and a use of the same.
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Inventors:
Atsushi Ikeda
Junichi Kikuchi
Junichi Kikuchi
Application Number:
JP2008557136A
Publication Date:
November 06, 2013
Filing Date:
February 06, 2008
Export Citation:
Assignee:
Nara Institute of Science and Technology
International Classes:
A61K33/44; A61K9/127; A61K41/00; A61K47/18; A61K47/24; A61K47/40; A61P9/10; A61P17/10; A61P17/12; A61P19/02; A61P27/02; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P35/00; A61K8/14; A61K8/19; A61K8/42; A61K8/55; A61K8/73; A61Q19/00
Domestic Patent References:
| JP2006069812A | 2006-03-16 |
Other References:
JPN6013013166; ＤＥＲＹＣＫＥ，Ａ．Ｓ． ｅｔ ａｌ: 'Ｌｉｐｏｓｏｍｅｓ ｆｏｒ ｐｈｏｔｏｄｙｎａｍｉｃ ｔｈｅｒａｐｙ' Ａｄｖ Ｄｒｕｇ Ｄｅｌｉｖ Ｒｅｖ Ｖｏｌ．５６， Ｎｏ．１, 2004, ｐ．１７-３０
JPN7008003155; ＩＫＥＤＡ，Ａ． ｅｔ ａｌ: 'Ａｎ ｅｘｔｒｅｍｅｌｙ ｅｆｆｅｃｔｉｖｅ ＤＮＡ ｐｈｏｔｏｃｌｅａｖａｇｅ ｕｔｉｌｉｚｉｎｇ ｆｕｎｃｔｉｏｎａｌｉｚｅｄ ｌｉｐｏｓｏｍｅｓ ｗｉｔｈ ａ ｆｕｌｌｅｒｅｎｅ-ｅｎｒｉｃｈｅ' Ｊ Ａｍ Ｃｈｅｍ Ｓｏｃ Ｖｏｌ．１２９， Ｎｏ．１４, 20070320, ｐ．４１４０-１
JPN7008003156; ＩＫＥＤＡ，Ａ． ｅｔ ａｌ: 'Ｅｆｆｉｃｉｅｎｔ ｐｈｏｔｏｃｌｅａｖａｇｅ ｏｆ ＤＮＡ ｕｔｉｌｉｓｉｎｇ ｗａｔｅｒ-ｓｏｌｕｂｌｅ ｌｉｐｉｄ ｍｅｍｂｒａｎｅ-ｉｎｃｏｒｐｏｒａｔｅｄ ［６０］ｆｕｌｌｅｒｅｎｅｓ ｐｒ' Ｏｒｇ Ｂｉｏｍｏｌ Ｃｈｅｍ Ｖｏｌ．３， Ｎｏ．１６, 2005, ｐ．２９０７-９
JPN6008016279; 池田篤志 他: '高濃度Ｃ６０内包リポソームの新調製法とそのＤＮＡ光切断能の評価' 高分子加工 Ｖｏｌ．５５， Ｎｏ．４, 2006, ｐ．１８０-１８４
JPN7008003157; 宮田直樹 他: 'フラ-レンの光増感生物作用に関与する反応活性種の解析' 薬学雑誌 Ｖｏｌ．１２０， Ｎｏ．１０, 2000, ｐ．１００７-１０１６
JPN6013013164; ＹＡＭＡＫＯＳＨＩ，Ｙ． ｅｔ ａｌ: 'Ａｃｔｉｖｅ ｏｘｙｇｅｎ ｓｐｅｃｉｅｓ ｇｅｎｅｒａｔｅｄ ｆｒｏｍ ｐｈｏｔｏｅｘｃｉｔｅｄ ｆｕｌｌｅｒｅｎｅ （Ｃ６０） ａｓ ｐｏｔｅｎｔｉａｌ ｍｅｄｉｃｉｎｅｓ： Ｏ２-＊ ｖｅｒｓｕ' Ｊ Ａｍ Ｃｈｅｍ Ｓｏｃ Ｖｏｌ．１２５， Ｎｏ．４２, 2003, ｐ．１２８０３-９
JPN6008016280; ＷＥＩ，Ｘ． ｅｔ ａｌ: 'Ｎｅｗ ｃｈｅｍｉｃａｌ ｍｅｔｈｏｄ ｆｏｒ ｓｅｌｅｃｔｉｖｅ ｇｅｎｅｒａｔｉｏｎ ｏｆ Ｃ７０｀ｎ-´（ｎ＝１，２，３） ａｎｉｏｎｓ ａｎｄ ｆｏｒｍａｔｉｏｎ ａｎｄ ｐｒｏｐｅｒｔｉ' Ｊ Ｃｈｅｍ Ｓｏｃ Ｐｅｒｋｉｎ Ｔｒａｎｓ ２ Ｎｏ．１, 1999, ｐ．１２１-１２６
JPN6013013166; ＤＥＲＹＣＫＥ，Ａ．Ｓ． ｅｔ ａｌ: 'Ｌｉｐｏｓｏｍｅｓ ｆｏｒ ｐｈｏｔｏｄｙｎａｍｉｃ ｔｈｅｒａｐｙ' Ａｄｖ Ｄｒｕｇ Ｄｅｌｉｖ Ｒｅｖ Ｖｏｌ．５６， Ｎｏ．１, 2004, ｐ．１７-３０
JPN7008003155; ＩＫＥＤＡ，Ａ． ｅｔ ａｌ: 'Ａｎ ｅｘｔｒｅｍｅｌｙ ｅｆｆｅｃｔｉｖｅ ＤＮＡ ｐｈｏｔｏｃｌｅａｖａｇｅ ｕｔｉｌｉｚｉｎｇ ｆｕｎｃｔｉｏｎａｌｉｚｅｄ ｌｉｐｏｓｏｍｅｓ ｗｉｔｈ ａ ｆｕｌｌｅｒｅｎｅ-ｅｎｒｉｃｈｅ' Ｊ Ａｍ Ｃｈｅｍ Ｓｏｃ Ｖｏｌ．１２９， Ｎｏ．１４, 20070320, ｐ．４１４０-１
JPN7008003155; ＩＫＥＤＡ，Ａ． ｅｔ ａｌ: 'Ａｎ ｅｘｔｒｅｍｅｌｙ ｅｆｆｅｃｔｉｖｅ ＤＮＡ ｐｈｏｔｏｃｌｅａｖａｇｅ ｕｔｉｌｉｚｉｎｇ ｆｕｎｃｔｉｏｎａｌｉｚｅｄ ｌｉｐｏｓｏｍｅｓ ｗｉｔｈ ａ ｆｕｌｌｅｒｅｎｅ-ｅｎｒｉｃｈｅ' Ｊ Ａｍ Ｃｈｅｍ Ｓｏｃ Ｖｏｌ．１２９， Ｎｏ．１４, 20070320, ｐ．４１４０-１
JPN7008003156; ＩＫＥＤＡ，Ａ． ｅｔ ａｌ: 'Ｅｆｆｉｃｉｅｎｔ ｐｈｏｔｏｃｌｅａｖａｇｅ ｏｆ ＤＮＡ ｕｔｉｌｉｓｉｎｇ ｗａｔｅｒ-ｓｏｌｕｂｌｅ ｌｉｐｉｄ ｍｅｍｂｒａｎｅ-ｉｎｃｏｒｐｏｒａｔｅｄ ［６０］ｆｕｌｌｅｒｅｎｅｓ ｐｒ' Ｏｒｇ Ｂｉｏｍｏｌ Ｃｈｅｍ Ｖｏｌ．３， Ｎｏ．１６, 2005, ｐ．２９０７-９
JPN6008016279; 池田篤志 他: '高濃度Ｃ６０内包リポソームの新調製法とそのＤＮＡ光切断能の評価' 高分子加工 Ｖｏｌ．５５， Ｎｏ．４, 2006, ｐ．１８０-１８４
JPN7008003157; 宮田直樹 他: 'フラ-レンの光増感生物作用に関与する反応活性種の解析' 薬学雑誌 Ｖｏｌ．１２０， Ｎｏ．１０, 2000, ｐ．１００７-１０１６
JPN6013013164; ＹＡＭＡＫＯＳＨＩ，Ｙ． ｅｔ ａｌ: 'Ａｃｔｉｖｅ ｏｘｙｇｅｎ ｓｐｅｃｉｅｓ ｇｅｎｅｒａｔｅｄ ｆｒｏｍ ｐｈｏｔｏｅｘｃｉｔｅｄ ｆｕｌｌｅｒｅｎｅ （Ｃ６０） ａｓ ｐｏｔｅｎｔｉａｌ ｍｅｄｉｃｉｎｅｓ： Ｏ２-＊ ｖｅｒｓｕ' Ｊ Ａｍ Ｃｈｅｍ Ｓｏｃ Ｖｏｌ．１２５， Ｎｏ．４２, 2003, ｐ．１２８０３-９
JPN6008016280; ＷＥＩ，Ｘ． ｅｔ ａｌ: 'Ｎｅｗ ｃｈｅｍｉｃａｌ ｍｅｔｈｏｄ ｆｏｒ ｓｅｌｅｃｔｉｖｅ ｇｅｎｅｒａｔｉｏｎ ｏｆ Ｃ７０｀ｎ-´（ｎ＝１，２，３） ａｎｉｏｎｓ ａｎｄ ｆｏｒｍａｔｉｏｎ ａｎｄ ｐｒｏｐｅｒｔｉ' Ｊ Ｃｈｅｍ Ｓｏｃ Ｐｅｒｋｉｎ Ｔｒａｎｓ ２ Ｎｏ．１, 1999, ｐ．１２１-１２６
JPN6013013166; ＤＥＲＹＣＫＥ，Ａ．Ｓ． ｅｔ ａｌ: 'Ｌｉｐｏｓｏｍｅｓ ｆｏｒ ｐｈｏｔｏｄｙｎａｍｉｃ ｔｈｅｒａｐｙ' Ａｄｖ Ｄｒｕｇ Ｄｅｌｉｖ Ｒｅｖ Ｖｏｌ．５６， Ｎｏ．１, 2004, ｐ．１７-３０
JPN7008003155; ＩＫＥＤＡ，Ａ． ｅｔ ａｌ: 'Ａｎ ｅｘｔｒｅｍｅｌｙ ｅｆｆｅｃｔｉｖｅ ＤＮＡ ｐｈｏｔｏｃｌｅａｖａｇｅ ｕｔｉｌｉｚｉｎｇ ｆｕｎｃｔｉｏｎａｌｉｚｅｄ ｌｉｐｏｓｏｍｅｓ ｗｉｔｈ ａ ｆｕｌｌｅｒｅｎｅ-ｅｎｒｉｃｈｅ' Ｊ Ａｍ Ｃｈｅｍ Ｓｏｃ Ｖｏｌ．１２９， Ｎｏ．１４, 20070320, ｐ．４１４０-１
Attorney, Agent or Firm:
Kenzo Hara International Patent Office