Title:
ＣＤ３結合ポリペプチド
Document Type and Number:
Japanese Patent JP7002446
Kind Code:
B2
Abstract:
The present disclosure relates to protein molecules that specifically bind to CD3, which may have at least one humanized CD3-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to CD3 may have a second binding domain that binds to another target. In one embodiment, multispecific polypeptide molecules bind both tumor antigen-expressing cells and the CD3 subunit of a T-cell receptor complex on T-cells to induce target-dependent T-cell cytotoxicity, activation, and proliferation. The disclosure also provides pharmaceutical compositions comprising the CD3-binding poypeptide molecules, nucleic acid molecules encoding these polypeptides and methods of making these molecules.
Inventors:
Tan, Philip
Blankenship, John W.
Blankenship, John W.
Application Number:
JP2018513821A
Publication Date:
March 04, 2022
Filing Date:
September 21, 2016
Export Citation:
Assignee:
Aptivo Research and Development LLC
International Classes:
C12N15/13; A61K38/16; A61K39/395; A61K47/68; A61P35/00; A61P35/02; C07K16/28; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63; C12P21/08
Domestic Patent References:
| JP2014517844A |
Foreign References:
| WO2014106602A1 | ||||
| WO2014072888A1 |
Other References:
熊谷 泉,リンパ球とがん細胞を認識するヒト型二重特異性抗体,Drug Delivery System,2008年,23-5,p.518-525
Nainong Li ,PNAS,2008年,vol.105,no.12,p.4796-4801
Nainong Li ,PNAS,2008年,vol.105,no.12,p.4796-4801
Attorney, Agent or Firm:
Ryoichi Takaoka
Nao Oda
Akiyo Iwahori
Kamoto Takahashi
Nao Oda
Akiyo Iwahori
Kamoto Takahashi