To obtain a new carbapenem compound useful as an antibiotic having a good oral absorption in addition to a wide antibacterial spectrum, a strong antibacetrial activity and good stability.
A compound of formula I [R1 is a (substituted) lower alkyl; R2 is H, a lower alkyl; R3 is H, a (substituted) hydrocarbon group, cyano, etc.; the cyclic group A is a (substituted) aromatic heterocyclic group not containing a quaternary nitrogen atom; when the cyclic group A is a pyridine ring, R3 is the group except H], its ester or salt. For example, (4R,5R,6S)-6-[(1R)-1- hydroxyethyl]-4-methyl-7-oxo-3-[2-(2-thiazolyl)ethylthio]-1-azabicyclo[3.2.0]hept-2- ene-2-carboxylic acid 4-nitrobenzyl ester. The compound of formula I is obtained by reacting a compound of formula II (L is a releasable group9 with a componud of formula III.
IMAMURA SHINICHI
MIWA TETSUO
