Title:
カルボン酸誘導体およびその塩
Document Type and Number:
Japanese Patent JP4131698
Kind Code:
B2
Abstract:
The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin sensitizer, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. Wherein R<1> represents a hydrogen atom, hydroxyl group, halogen, carboxyl group, or a C1-6 alkyl group etc., each of which may have one or more substituents; L represents a single bond, or a C1-6 alkylene group, a C2-6 alkenylene group or a C2-6 alkynylene group, each of which may have one or more substituents; M represents a single bond, or a C1-6 alkylene group, a C2-6 alkenylene group or a C2-6 alkynylene group, each of which may have one or more substituents; T represents a single bond, or a C1-3 alkylene group, a C2-3 alkenylene group or a C2-3 alkynylene group, each of which may have one or more substituents; W represents a carboxyl group; - - - represents a single bond etc. ; X represents a single bond, oxygen atom, a group represented by -NRCQ<1>O- (wherein Q<1> represents an oxygen atom or sulfur atom; and R represents a hydrogen atom, formyl group, or a C1-6 alkyl group etc., each of which may have one or more substituents), -OCQ<1>NR- (wherein Q<1> and R are as defined above), -CQ<1>NRO- (wherein Q<1> and R are as def ined above), ONRCQ<1>- (wherein Q<1> and R are as defined above), - Q<2>SO2- (wherein Q<2> is an oxygen atom or -NR- (wherein R represents a hydrogen atom, formyl group, or a C1-6 alkyl group etc., each of which may have one or more substituents)) or -SO2Q<2>- (wherein Q<2> is as defined above), (wherein, provided that R and R, and/or R and R may together form a ring, Q<3> and Q<4> are the same as or different from each other and each represents an oxygen atom, (O)S(O) or NR (wherein NR is as defined above)); Y represents a 5- to 14-membered aromatic group etc., which may have one or more substituents and one or more hetero atoms; and the ring Z represents a 5-to 14-membered aromatic group which may have 0 to 4 substituents and one or more hetero atoms, and wherein part of the ring may be saturated.
Inventors:
Fumiyoshi Matsuura
Eita Emori
Masanobu Shinoda
Clark richard
Shunji Kasai
Kato Hideki
Yamazaki Kazuto
Kei Inoue
Miyashita Sadakazu
Taro Hihara
Harada Hitoshi
Kaya Ohashi
Eita Emori
Masanobu Shinoda
Clark richard
Shunji Kasai
Kato Hideki
Yamazaki Kazuto
Kei Inoue
Miyashita Sadakazu
Taro Hihara
Harada Hitoshi
Kaya Ohashi
Application Number:
JP2003503583A
Publication Date:
August 13, 2008
Filing Date:
April 18, 2002
Export Citation:
Assignee:
Eisai R & D Management Co., Ltd.
International Classes:
C07C59/64; A61K31/192; C07C59/68; A61K31/27; A61K31/275; A61K31/40; A61K31/404; A61K31/44; A61K31/4402; A61K31/4453; A61K31/47; A61P1/00; A61P1/04; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P19/10; A61P25/28; A61P29/00; A61P35/00; A61P37/02; A61P43/00; C07C59/58; C07C59/72; C07C233/25; C07C235/24; C07C251/48; C07C251/52; C07C251/54; C07C255/37; C07C255/54; C07C259/10; C07C271/14; C07C271/16; C07C271/22; C07C271/28; C07C271/58; C07C309/73; C07C309/75; C07C311/19; C07C317/18; C07C317/22; C07C323/20; C07D209/08; C07D209/18; C07D209/24; C07D209/32; C07D213/30; C07D213/64; C07D213/65; C07D213/68; C07D213/73; C07D213/75; C07D213/78; C07D215/14; C07D215/18; C07D215/22; C07D215/26; C07D235/06; C07D235/12; C07D277/56; C07D295/08; C07D295/096; C07D295/18; C07D295/192; C07D307/79; C07D317/54; C07D413/12; C07D417/12
Domestic Patent References:
| JP51125238A | ||||
| JP53007638A | ||||
| JP2000503643A |
Foreign References:
| DE3026924A | ||||
| WO2001025181A1 | ||||
| WO1999004815A1 | ||||
| WO1999008501A1 | ||||
| WO1999038850A1 |
Attorney, Agent or Firm:
Satoshi Furuya
Takahiko Mizobe
Shinji Mochida
Yoshitsune Kazumasa
Takahiko Mizobe
Shinji Mochida
Yoshitsune Kazumasa