NEW MATERIAL:A compound expressed by formula I (R1 is H, lower alkyl or aryl) or salt thereof.
EXAMPLE: Diethyl 2-benzoyloxy-2-ethoxycarbonyl-3-methyl-glutarate.
USE: A dehydropeptidase I inhibitor administered to humans or animals requiring antibiotic therapy simultaneously with a carbapenem based antibiotic substance.
PREPARATION: A microorganism, belonging to the genus Streptomyces and capable of producing a compound expressed by formula II (Ra1 is H or methyl) is cultivated in a culture medium to provide a compound expressed by formula II or salt thereof from the resultant culture. Streptomyces sp. No.1358 (FERM-P No.1638) is used as the microorganism capable of producing the compound expressed by formula II. The cultivation is preferably carried out under aerobic condition of, e.g. shaking culture or submerged culture.
HATANAKA HIROSHI
NITTA KUMIKO
HASHIMOTO MASAHARU
OKUHARA MASAKUNI
UCHIDA ITSURO
HASHIMOTO SHINJI
