Title:
CATCHING OF COMPOUND IN STEROL VESICLE
Document Type and Number:
Japanese Patent JP2706649
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To prove a method for catching a biologically active substance in a sterol vesicle suitable for administration in vivo so as to facilitate use of a water-soluble active substance and administration of a water-insoluble active substance.
SOLUTION: This method for catching of a water-insoluble compound in a sterol vesicle comprises dissolving a water-insoluble compound in an organic solvent, removing the organic solvent to leave a film consisting of the water- insoluble compound and adding a sterol vesicle composed of a salt of a sterol organic derivative to the film. Alternatively, the water-insoluble compound and an organic acid derivative of a sterol in a state of a salt, capable of forming a double layer in an organic solvent are both dissolved in the organic solvent, the organic solvent is evaporated to leave a film containing the compound and the organic acid derivative of the sterol in a state of a salt and an aqueous phase is added to the film and shaken so that a milk white suspension of a completely closed multilamella vesicle is formed to give the objective method for catching the water-soluble compound in the sterol vesicle.
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Inventors:
Janov, Andrew S
Popesque, Mercy C
Weiner, Alan El
Volksaku, Louis Yi
Torem Bray, Paul A.
Popesque, Mercy C
Weiner, Alan El
Volksaku, Louis Yi
Torem Bray, Paul A.
Application Number:
JP19170796A
Publication Date:
January 28, 1998
Filing Date:
July 22, 1996
Export Citation:
Assignee:
The Liposome Company, Inc.
International Classes:
A61K9/127; A61K47/28; B01J13/02; G01N33/544; (IPC1-7): A61K9/127; A61K47/28; B01J13/02
Attorney, Agent or Firm:
Akitoshi Otawa (1 outside)