Title:
CELL-SEEDED COMPOSITIONS AND METHODS USEFUL FOR TREATING BONE REGIONS
Document Type and Number:
Japanese Patent JP2022122293
Kind Code:
A
Abstract:
To provide compositions and treatment methods for treating diseased or damaged bone, preferably ischemic and/or necrotic bone.SOLUTION: A composition includes endothelial progenitor cells (EPCs), mesenchymal stem cells (MSCs), and a solid carrier material. The composition includes the EPCs and MSCs in a cell number ratio of at least about 2:1. The solid carrier material includes a collagenous extracellular matrix (ECM) tissue material. The ECM tissue material retains native bioactive substances from a source tissue for the ECM tissue material. The native bioactive substances include growth factors, glycosaminoglycans, proteoglycans and glycoproteins, are retained by the ECM tissue material as solids interspersed between, upon and/or within collagen fibers of the ECM tissue material, and constitute at least 1% of the dry weight of the ECM tissue material. At least 50% of the total number of the EPCs and MSCs in the composition are attached to the solid carrier material.SELECTED DRAWING: None
Inventors:
SHELLEY L WALLACE
AMANDA F TAYLOR
STEVEN CHARLEBOIS
CHRISTINE M STEINHART
NEAL E FEARNOT
AMANDA F TAYLOR
STEVEN CHARLEBOIS
CHRISTINE M STEINHART
NEAL E FEARNOT
Application Number:
JP2022081533A
Publication Date:
August 22, 2022
Filing Date:
May 18, 2022
Export Citation:
Assignee:
MUFFIN INC
International Classes:
A61K35/51; A61K35/22; A61K35/28; A61K35/44; A61K47/42; A61P19/08
Attorney, Agent or Firm:
Shigeru Ito
Shrimp Yusuke
Shrimp Yusuke
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