COMBINATION OF DIAMIDE DERIVATIVE AND IMMUNOSUPPRESSANT TO INDUCE IMMUNE TOLERANCE

Title:

COMBINATION OF DIAMIDE DERIVATIVE AND IMMUNOSUPPRESSANT TO INDUCE IMMUNE TOLERANCE

Document Type and Number:

Japanese Patent JP2011016851

Kind Code:

A

Abstract:

To provide a method to induce an immune tolerance.

A method to induce an immune tolerance by an administration of an immunosuppressant and a compound shown by formula I is disclosed. In addition, a method to inhibit an immune response by the administration of the immunosuppressant and the compound shown by formula I is disclosed. Additionally, a method for treatment of an autoimmune disease by the administration of the immunosuppressant and the compound shown by formula I is disclosed. Furthermore, a method for prevention, inhibition or suppression of rejection to a transplanted organ, and the method for treatment of the autoimmune disease are disclosed. Still furthermore, a method to induce a specific immune tolerance to the transplanted organ without causing loss of a non-specific immunity by a combination therapy of administration of rapamycin below a therapeutic dose together with the compound shown by formula I to a heart transplanted mouse is disclosed.

Inventors:

WILLIAMS JOHN M

Application Number:

JP2010236925A

Publication Date:

January 27, 2011

Filing Date:

October 21, 2010

Export Citation:

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Assignee:

GENZYME CORP

International Classes:

A61K31/417; A61K31/16; A61K31/4174; A61K31/436; A61K31/4375; A61K39/395; A61K45/06; A61P37/06; C07K16/28

Domestic Patent References:

JPH0373158A	1991-03-28
JP2001508450A	2001-06-26
JP4914008B2	2012-04-11

Foreign References:

WO2001087849A2

2001-11-22

Attorney, Agent or Firm:

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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