Title:
薬物を内包するリポソーム組成物および免疫チェックポイント阻害剤を含む組合せ医薬
Document Type and Number:
Japanese Patent JP7036919
Kind Code:
B2
Abstract:
An object of the present invention is to provide a pharmaceutical formulation obtained by combining a liposome composition in which liposomes encapsulate a drug with an immune checkpoint inhibitor. According to the present invention, there is provided a pharmaceutical formulation including (A) a liposome composition in combination with (B) an immune checkpoint inhibitor, in which the liposome composition includes, as constitutional components of a liposome membrane, a hydrophilic polymer-modified diacylphosphatidylethanolamine; a dihydrosphingomyelin; and cholesterols, the liposome composition includes a drug and has an inner water phase containing ammonium sulfate, a molar ratio of sulfate ions in the inner water phase to the drug in an entire water phase is 0.36 or more, and the liposome composition and the immune checkpoint inhibitor are administered simultaneously or sequentially.
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Inventors:
Shin Shimoyama
Tadaaki Gohyakuzo
Mori Nagano
Tamami Higuchi
Tadaaki Gohyakuzo
Mori Nagano
Tamami Higuchi
Application Number:
JP2020525795A
Publication Date:
March 15, 2022
Filing Date:
June 20, 2019
Export Citation:
Assignee:
FUJIFILM Corporation
International Classes:
A61K9/127; A61K31/404; A61K31/4745; A61K31/704; A61K45/00; A61K47/02; A61K47/24; A61K47/28; A61P35/00; A61P43/00
Domestic Patent References:
| JP2017512840A |
Foreign References:
| WO2017079303A1 | ||||
| WO2017078008A1 | ||||
| WO2012091054A1 |
Other References:
FUGIT KD. et al.,Ion-Pairing Contribution to the Liposomal Transport of Topotecan as Revealed by Mechanistic Modeling,Journal of Pharmaceutical Sciences,2017年,Vol.106,p.1149-1161,Materials and Methods
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes
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