Title:
ニコチン禁断症状および/またはタバコ使用の軽減用組成物
Document Type and Number:
Japanese Patent JP2010505960
Kind Code:
A
Abstract:
Compositions useful for treating an individual with nicotine dependence comprising a combination of an α3β4 nicotinic receptor antagonist and a nicotine metabolite are disclosed. More particularly, compositions comprising cotinine or a pharmaceutically acceptable salt thereof are disclosed. Methods of alleviating nicotine withdrawal symptoms and/or tobacco usage by administration of these compositions are also disclosed.
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Inventors:
Shin Yue Chang
Charlotte A. Lemons
Charlotte A. Lemons
Application Number:
JP2009532516A
Publication Date:
February 25, 2010
Filing Date:
October 08, 2007
Export Citation:
Assignee:
GlaxoSmithKline LLC
International Classes:
A61K45/06; A61K9/00; A61K9/20; A61K9/48; A61K31/4439; A61K31/485; A61K47/42; A61P25/34; A61P43/00
Domestic Patent References:
| JP2002532392A | 2002-10-02 | |||
| JP2001518520A | 2001-10-16 | |||
| JPH07508036A | 1995-09-07 | |||
| JP2005500975A | 2005-01-13 |
Other References:
JPN6012035768; Ｈｅｒｎａｎｄｅｚ，Ｓ．Ｃ． ｅｔ ａｌ．: 'Ｄｅｘｔｒｏｍｅｔｈｏｒｐｈａｎ ａｎｄ ｉｔｓ ｍｅｔａｂｏｌｉｔｅ ｄｅｘｔｒｏｒｐｈａｎ ｂｌｏｃｋ ａｌｐｈａ３ｂｅｔａ４ ｎｅｕｒｏｎａｌ ｎｉｃｏｔｉｎｉｃ ｒｅｃｅｐｔｏｒｓ' Ｊ． Ｐｈａｒｍａｃｏｌ． Ｅｘｐ． Ｔｈｅｒ． Ｖｏｌ．２９３，Ｎｏ．３, 20000601, Ｐ．９６２-９６７
JPN6012035771; Ｇｌｉｃｋ，Ｓ．Ｄ． ｅｔ ａｌ．: 'Ｃｏｍｐａｒａｔｉｖｅ ｅｆｆｅｃｔｓ ｏｆ ｄｅｘｔｒｏｍｅｔｈｏｒｐｈａｎ ａｎｄ ｄｅｘｔｒｏｒｐｈａｎ ｏｎ ｍｏｒｐｈｉｎｅ， ｍｅｔｈａｍｐｈｅｔａｍｉｎｅ， ａｎｄ ｎｉｃｏｔｉｎｅ ｓ' Ｅｕｒ． Ｊ． Ｐｈａｒｍａｃｏｌ． Ｖｏｌ．４２２，Ｎｏ．１-３, 20010622, Ｐ．８７-９０
JPN6012035771; Ｇｌｉｃｋ，Ｓ．Ｄ． ｅｔ ａｌ．: 'Ｃｏｍｐａｒａｔｉｖｅ ｅｆｆｅｃｔｓ ｏｆ ｄｅｘｔｒｏｍｅｔｈｏｒｐｈａｎ ａｎｄ ｄｅｘｔｒｏｒｐｈａｎ ｏｎ ｍｏｒｐｈｉｎｅ， ｍｅｔｈａｍｐｈｅｔａｍｉｎｅ， ａｎｄ ｎｉｃｏｔｉｎｅ ｓ' Ｅｕｒ． Ｊ． Ｐｈａｒｍａｃｏｌ． Ｖｏｌ．４２２，Ｎｏ．１-３, 20010622, Ｐ．８７-９０
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita
Nishino Mitsuru
Mizuhara Masahiro
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita
Nishino Mitsuru
Mizuhara Masahiro