PURPOSE: To provide the subject composition containing, as active component, anti-coagulant nonionic contrast agents, wherein some of the agents are new compounds, and having the ability to reduce the risk of clot formation in diagnostic procedures(in detail, X-ray impermeable compounds are needed in the diagnostic procedures).
CONSTITUTION: The composition is comprised of (A) anti-coagulant nonionic contrast agents and (B) pharmaceutically acceptable carriers, wherein the compounds used as components of A are iodinated phenyl-compounds having a heterocyclic group, preferably the compounds having radical of formula I (the hetro cyclic group is formula II-VI; R, R' are H, alkyl, OH, alkoxy, hydroxyalkyl or alkoxyalkyl; X1 is =N-CO-H, =N-CO-alkyl, S, or O; X2 is X1 or CH2; (n) is 1-4, or (n) is 0-4 when X2 is CH2; (n) is 0-3; (s),(p) are each 2-5; (g), (r) are each 1 or 2) or its dimer, wherein some of the compounds mentioned above are new compounds. The compound of formula IV [R1 is CONR4R6; R2 is CONR6R7, etc.; R4, R5 are each H, CH3, etc.; R6, R7 are each H, CH2CH(OH)CH2OH, etc.] in the compounds mentioned above are new compounds.
MAIKERU EFU TSUIIDORU
POORU DABURIYUU UEDEKINGU
RADAKURISHIYUNA PIRAI
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