Title:
ＮＫ細胞を増幅するための組成物及び方法
Document Type and Number:
Japanese Patent JP5840876
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To develop technique capable of amplifying cells having high NK cell purity, high NK cell amplification magnification and little commingling of T cells, even from umbilical cord blood and peripheral blood without using feeder cells.SOLUTION: There are provided a composition for amplifying natural killer cells (NK cells) containing one or more kinds of compounds selected from the group consisting of tacrolimus, derivatives and salts thereof, and dalteparin, derivatives and salts thereof; and a method for amplifying the NK cells including a step of preparing the NK cells and a step of incubating the NK cells in the presence of one or more kinds of compounds selected from the group consisting of tacrolimus, derivatives and salts thereof, and dalteparin, derivatives and salts thereof.
Inventors:
Junji Tanaka
Application Number:
JP2011140504A
Publication Date:
January 06, 2016
Filing Date:
June 24, 2011
Export Citation:
Assignee:
Terra Corporation
International Classes:
C12N5/0783; A61K31/706; A61K31/727; A61K35/12; A61K35/14; A61K35/16; A61K35/17; A61K35/28; A61K35/44; A61K35/51; A61K35/545; A61K38/00; A61K39/395; A61P31/00; A61P35/00; A61P37/04; A61P43/00; C12N5/0735; C12N5/0789; C12N5/10
Foreign References:
| WO2008153150A1 | ||||
| WO2010013947A2 |
Other References:
Int. J. Immunopharmacol.,1993年 2月,Vol.15,No.2,pp.211-218
日本呼吸器学会雑誌,日本,2004年 3月,Vol.42,Suppl.2,p.180,#P117
Transplantation,1991年 4月,Vol.51,No.4,pp.913-915
日本呼吸器学会雑誌,日本,2004年 3月,Vol.42,Suppl.2,p.180,#P117
Transplantation,1991年 4月,Vol.51,No.4,pp.913-915
Attorney, Agent or Firm:
Masahiro Nanjo
Ayako Seta
Koichiro Inami
Hidetoshi Hara
Ayako Seta
Koichiro Inami
Hidetoshi Hara