Title:
COMPOSITIONS AND METHODS FOR PREVENTION OF OXIDATIVE DEGRADATION OF PROTEINS
Document Type and Number:
Japanese Patent JP2015107973
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide: use of aromatic compounds as stabilizers to prevent oxidative degradation of proteins, particularly tryptophan, tyrosine or histidine residues; and more specifically, stabilized, pharmaceutically effective formulations of oxidation-sensitive therapeutic agents, and a method of inhibiting oxidation of such therapeutic agents.SOLUTION: The invention relates to pharmaceutical formulations comprising a protein and free methionine in combination with one or more compounds capable of preventing oxidation of aromatic amino acid residues within a protein. More specifically, the invention relates to pharmaceutical formulations comprising a protein, free methionine and the one or more compounds capable of preventing oxidation of aromatic amino acid residues within a protein.
Inventors:
JUNYAN A JI
WANG YUCHANG JOHN
ZHANG BOYAN
WANG YUCHANG JOHN
ZHANG BOYAN
Application Number:
JP2014249972A
Publication Date:
June 11, 2015
Filing Date:
December 10, 2014
Export Citation:
Assignee:
GENENTECH INC
International Classes:
A61K47/18; A61K9/08; A61K47/10; A61K47/22; A61K47/26; C07K16/18
Domestic Patent References:
| JP2000247903A | 2000-09-12 | |||
| JP2005500982A | 2005-01-13 | |||
| JP2000262278A | 2000-09-26 |
Foreign References:
| WO2001064241A1 | 2001-09-07 |
Other References:
JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS,1994,VOL.29,NO.1,P.77-81, JPN6014022777, ISSN: 0003196590
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori
Previous Patent: AGENTS THAT REDUCE NEURONAL OVEREXCITATION
Next Patent: METHODS FOR THE TREATMENT OF CANCER
Next Patent: METHODS FOR THE TREATMENT OF CANCER