Title:
METHODS FOR THE TREATMENT OF CANCER
Document Type and Number:
Japanese Patent JP2015107974
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a method for treating glioblastoma or colorectal cancer by using at least one hepatocyte growth factor (HGF)-Met inhibitor and at least one epidermal growth factor receptor (EGFR) inhibitor.SOLUTION: A pharmaceutical composition of the invention comprises an HGF-Met inhibitor to be administered with an EGFR inhibitor, where the HGF-Met inhibitor is antibody 2.12.1, and the EGFR inhibitor is panitumumab (an antibody against EGFR), suitable for administration of a therapeutically effective amount of the HGF-Met inhibitor, concurrent with, prior to, or subsequent to the administration of the EGFR inhibitor.
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Inventors:
TERRANCE JOHNS
Application Number:
JP2014256872A
Publication Date:
June 11, 2015
Filing Date:
December 19, 2014
Export Citation:
Assignee:
LUDWIG INST FOR CANCER RES LTD
International Classes:
A61K39/395; A61K45/00; A61P35/00; A61P43/00
Domestic Patent References:
| JP2007530003A | 2007-11-01 |
Other References:
JPN6013045911; Ｆｏｌｉａ Ｎｅｕｒｏｐａｔｈｏｌ． Ｖｏｌ．４３ Ｎｏ．３, 2005, ｐｐ．１２３-１３２
JPN6013045913; Ｎａｔ． Ｒｅｖ． Ｄｒｕｇ Ｄｉｓｃｏｖ． Ｖｏｌ．７ Ｎｏ．６, 200806, ｐｐ．５０４-５１６
JPN6014035094; Ｓｅｍｉｎ． Ｏｎｃｏｌ． Ｖｏｌ．３２, 2005, ｐｐ．５２-６０
JPN6014035097; Ｃａｎｃｅｒ Ｖｏｌ．１１０, 2007, ｐｐ．９８０-９８８
JPN6014035098; Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． Ｖｏｌ．１０４ Ｎｏ．２７, 2007, ｐｐ．１１４１２-１１４１７
JPN6014035099; Ｗｏｒｌｄ Ｊ． Ｇａｓｔｒｏｅｎｔｅｒｏｌ． Ｖｏｌ．１１ Ｎｏ．２５, 2005, ｐｐ．３８７７-３８８１
JPN6013045913; Ｎａｔ． Ｒｅｖ． Ｄｒｕｇ Ｄｉｓｃｏｖ． Ｖｏｌ．７ Ｎｏ．６, 200806, ｐｐ．５０４-５１６
JPN6014035094; Ｓｅｍｉｎ． Ｏｎｃｏｌ． Ｖｏｌ．３２, 2005, ｐｐ．５２-６０
JPN6014035097; Ｃａｎｃｅｒ Ｖｏｌ．１１０, 2007, ｐｐ．９８０-９８８
JPN6014035098; Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． Ｖｏｌ．１０４ Ｎｏ．２７, 2007, ｐｐ．１１４１２-１１４１７
JPN6014035099; Ｗｏｒｌｄ Ｊ． Ｇａｓｔｒｏｅｎｔｅｒｏｌ． Ｖｏｌ．１１ Ｎｏ．２５, 2005, ｐｐ．３８７７-３８８１
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto