Title:
COMPOSITIONS AND METHODS FOR TREATING AUTOIMMUNE DISEASES AND CANCERS
Document Type and Number:
Japanese Patent JP2023096078
Kind Code:
A
Abstract:
To provide compositions and methods for treating autoimmune diseases and cancers.SOLUTION: The present invention provides methods and compositions for treating a cancer, methods for increasing an immune response to a tumor, methods for treating an autoimmune disease, and methods for decreasing an inflammation response in a subject in need thereof by modulating the expression and/or activity of Siglec 15 and/or its binding ligands. A method of treating a cancer in a subject in need of treatment of the cancer comprises administering to the subject an effective amount of a modulator of Siglec 15, where the modulator decreases the expression and/or activity of Siglec 15 in the subject, thereby treating the cancer in the subject.SELECTED DRAWING: None
Inventors:
CHEN LIEPING
WANG JUN
SUN JINGWEI
WANG JUN
SUN JINGWEI
Application Number:
JP2023081549A
Publication Date:
July 06, 2023
Filing Date:
May 17, 2023
Export Citation:
Assignee:
UNIV YALE
International Classes:
A61K45/00; A61K38/00; A61K39/395; A61P25/00; A61P35/00; A61P37/06; C12Q1/6837
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Natsuki Morishita