Title:
細胞生存率を向上させるための組成物およびその使用方法
Document Type and Number:
Japanese Patent JP7242945
Kind Code:
B2
Abstract:
This invention relates to methods and compositions for use improving cell viability, particularly neural cell viability, and more particularly to methods and compositions for use improving cell viability by reducing reactive oxygen metabolite-mediated oxidative damage in a cell, regulating redox homeostasis in a cell, or reducing mitochondrial dysfunction in a cell. The invention further relates to the administration of the bile acid tauroursodeoxycholic acid (TUDCA) in combination with phenylbutyric Acid (PBA) to improve cell viability, and treat at least one symptom associated with, prevent the time of onset of, or slow the development of a disease related to oxidative stress.
Inventors:
Joshua B. Cohen
Justin Kelly
Justin Kelly
Application Number:
JP2022085433A
Publication Date:
March 20, 2023
Filing Date:
May 25, 2022
Export Citation:
Assignee:
Amy Lix Pharmaceuticals, Inc.
International Classes:
A61K31/575; A61K31/192; A61P21/00; A61P25/00; A61P43/00
Domestic Patent References:
| JP2016515575A | ||||
| JP2008518935A | ||||
| JP2011518119A |
Other References:
N. ENGL. J. MED.,2020年09月03日,Vol.383,pp.919-930
Attorney, Agent or Firm:
Patent Attorney Corporation Suzue Patent General Office
Masatoshi Kurata
Tadashi Inoue
Shigeru Iino
Naoki Kono
Sanae Kaneko
Masatoshi Kurata
Tadashi Inoue
Shigeru Iino
Naoki Kono
Sanae Kaneko