Title:
COMPOUND AS PDE IV AND TNF INHIBITOR
Document Type and Number:
Japanese Patent JP2010195787
Kind Code:
A
Abstract:
To provide a compound useful for PDE IV and TNF inhibitor.
There is provided a compound, an N-oxide, or a pharmaceutically acceptable salt of the formula wherein R1 is optionally substituted lower alkyl; R2 is optionally substituted cycloalkyl or the like; R3 is optionally substituted aryl or heteroaryl; Q1, Q2 and Q3 are independently nitrogen, CX or CH, provided that at least one of Q1, Q2 and Q3 is not CH; Z1 and Z2 are independently oxygen or sulfur; Z3 is -CH=CH-, -CZCH2-, -CZ-CZ-, -CH2-NH-, -CH2-O-, -CX2-O-, -CH2-S-, or the like; Z is oxygen or sulfur; and X is a halogen.
Inventors:
FENTON GARRY
MAJID TAHIR NADEEM
PALFREYMAN MALCOLM NORMAN
MAJID TAHIR NADEEM
PALFREYMAN MALCOLM NORMAN
Application Number:
JP2010050508A
Publication Date:
September 09, 2010
Filing Date:
March 08, 2010
Export Citation:
Assignee:
AVENTIS PHARMA LTD (GB)
International Classes:
C07C43/247; A61K31/09; C07D239/42; A61K31/137; A61K31/165; A61K31/167; A61K31/196; A61K31/42; A61K31/425; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4412; A61K31/4418; A61K31/4425; A61K31/4439; A61K31/444; A61K31/455; A61K31/495; A61K31/4965; A61K31/50; A61K31/501; A61K31/505; A61K31/53; A61P1/04; A61P3/10; A61P7/12; A61P11/00; A61P11/06; A61P11/08; A61P13/12; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P19/02; A61P19/08; A61P25/00; A61P25/28; A61P27/16; A61P29/00; A61P31/00; A61P31/04; A61P35/02; A61P37/06; A61P37/08; A61P43/00; C07C43/225; C07C217/58; C07C217/64; C07C235/56; C07C237/30; C07C255/60; C07C317/14; C07C317/40; C07C323/20; C07C323/65; C07C325/02; C07C327/42; C07C327/48; C07D213/50; C07D213/61; C07D213/65; C07D213/66; C07D213/69; C07D213/70; C07D213/75; C07D213/80; C07D213/81; C07D213/82; C07D213/89; C07D237/14; C07D239/46; C07D241/18; C07D241/20; C07D253/06; C07D261/14; C07D275/02; C07D401/12; C07D413/12; A61P11/02; A61P25/16; A61P31/12; A61P31/18; A61P33/00
Domestic Patent References:
| JPH0616559A | 1994-01-25 |
Foreign References:
| WO1992012961A1 | 1992-08-06 |
Attorney, Agent or Firm:
Patent business corporation Odashima patent office