COMPOUND AND DRUG COMPOSITION

Title:

COMPOUND AND DRUG COMPOSITION

Document Type and Number:

Japanese Patent JPS559074

Kind Code:

A

Abstract:

Bicyclo[3.1.0] hexyl-substituted carbonylaminophenoxy compounds of the formula where R is i-propyl or t-butyl; R<2> is H, halo, CN, C1-2 alkyl, C1-2 alkoxy, acetyl or propionyl; Y is >NR<5> where R<5> is H or methyl; n is 0 or 1 and m is 1 or 2; and their pharmaceutically acceptable salts; and pharmaceutical compositions containing such compounds, can be used for treating cardiac disorders, hypertension and glaucoma in mammals, and may have local anesthetic properties. They can be prepared by reaction of isopropylamine or t-butylamine with the corresponding compound having in place of -OCH2CH(OH)CH2NHR, or by hydrolysing the corresponding compound having in place of -OCH2CH(OH)CH2NHR, in which R<3> is H, alkyl or optionally substituted carbocyclic aryl.

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Inventors:

KAARU JIYOOJI ANCHI
BERIGU MEEMETO BAAKOZU
SUTEFUAN HOWAADO ANGAA

Application Number:

JP8153979A

Publication Date:

January 22, 1980

Filing Date:

June 29, 1979

Export Citation:

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Assignee:

SYNTEX INC

International Classes:

A61K31/16; A61K31/138; A61K31/165; A61K31/275; A61P9/00; A61P9/06; A61P9/12; A61P25/02; A61P27/02; A61P27/06; C07C53/136; C07C67/00; C07C239/00; C07C253/00; C07C255/59; C07C275/34; C07D263/06; C07D303/22; (IPC1-7): A61K31/16; A61K31/275; C07C103/737; C07C121/80; C07C127/19

Next Patent: ASCORBIC ACID DERIVATIVE, ITS PRODUCTION AND USE