Title:
COMPOUND AND METHOD FOR THERAPY OF INFLAMMATORY AND FIBROTIC DISEASE
Document Type and Number:
Japanese Patent JP2014210809
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a compound and method for therapy of inflammatory and fibrotic diseases.SOLUTION: Disclosed are a compound and method for therapy of inflammatory diseases and fibrotic diseases, including a method of regulating stress-activated protein kinase (SAPK) with an active compound, where the active compound exhibits low efficacy due to inhibition of p38MAPK; contacting is conducted at a SAPK regulate concentration which is a low percentage of inhibition concentration for inhibition of p38MAPK by the compound. Disclosed are also a derivative and analog of pirfenidone useful for regulating a stress-activated protein kinase (SAPK) system.
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Inventors:
KARL KOSSEN
SCOTT D SEIWERT
VLADIMIR SEREBRYANY
DONALD RUHRMUND
LEONID BEIGELMAN
LUCA FRANCESCO MARIO RAVEGLIA
STEFANIA VALLESE
IVANA BIANCHI
HU TAO
SCOTT D SEIWERT
VLADIMIR SEREBRYANY
DONALD RUHRMUND
LEONID BEIGELMAN
LUCA FRANCESCO MARIO RAVEGLIA
STEFANIA VALLESE
IVANA BIANCHI
HU TAO
Application Number:
JP2014161019A
Publication Date:
November 13, 2014
Filing Date:
August 07, 2014
Export Citation:
Assignee:
INTERMUNE INC
International Classes:
C07D213/64; A61K31/437; A61K31/4412; A61K31/443; A61K31/4433; A61K31/4436; A61K31/4439; A61K31/444; A61K31/496; A61K31/4965; A61K31/50; A61K31/506; A61K31/513; A61K31/53; A61K31/5377; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P5/16; A61P7/00; A61P7/02; A61P7/04; A61P7/06; A61P9/00; A61P9/04; A61P11/00; A61P11/06; A61P13/02; A61P13/12; A61P17/06; A61P17/08; A61P19/02; A61P19/06; A61P19/08; A61P19/10; A61P21/00; A61P21/04; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P31/00; A61P31/04; A61P31/16; A61P31/18; A61P31/22; A61P33/02; A61P33/06; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07D213/69; C07D213/70; C07D213/75; C07D213/85; C07D237/14; C07D239/10; C07D239/22; C07D239/36; C07D239/54; C07D241/18; C07D251/16; C07D401/04; C07D401/14; C07D405/04; C07D405/14; C07D409/04; C07D413/04; C07D413/14; C07D417/04; C07D471/04
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Natsuki Morishita
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