Title:
TPO模倣剤としての化合物および組成物
Document Type and Number:
Japanese Patent JP5175730
Kind Code:
B2
Abstract:
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia.
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Inventors:
Thomas Marsille
Wenshuo LU
Philip Alper
Daniel Mattnick
Yoon Hee
Wenshuo LU
Philip Alper
Daniel Mattnick
Yoon Hee
Application Number:
JP2008527105A
Publication Date:
April 03, 2013
Filing Date:
August 15, 2006
Export Citation:
Assignee:
IRM,LLC
International Classes:
C07D209/10; C07D209/14; C07D209/18; A61K31/404; A61K31/4184; A61P7/00; A61P43/00; C07D235/18
Domestic Patent References:
| JP2003503490A | ||||
| JP2306916A | ||||
| JP55033479A | ||||
| JP51006980A | ||||
| JP2003503390A | ||||
| JP59027875A | ||||
| JP3014579A | ||||
| JP2008528578A | ||||
| JP2001097948A | ||||
| JP2003515560A |
Foreign References:
| WO2005009993A1 | ||||
| NL6510290A | ||||
| WO2005042497A1 | ||||
| US20010024833 | ||||
| WO2004054515A1 |
Other References:
ABUZAR,S. et al.,Synthesis of substituted benzimidazoles as potential anthelminthics,Archiv der Pharmazie(Weinheim, Germany),1982年,Vol.315, No.10,p.866-871
SUN,Q. et al.,Single bead IR monitoring of a novel benzimidazole synthesis,Bioorganic & Medicinal Chemistry Letters,1998年,Vol.8, No.4,p.361-364
LOMBARDY,R.L. et al.,Synthesis and DNA interactions of benzimidazole dications which have activity against opportunistic infections,Journal of Medicinal Chemistry,1996年,Vol.39, No.7,p.1452-1462
SUN,Q. et al.,Single bead IR monitoring of a novel benzimidazole synthesis,Bioorganic & Medicinal Chemistry Letters,1998年,Vol.8, No.4,p.361-364
LOMBARDY,R.L. et al.,Synthesis and DNA interactions of benzimidazole dications which have activity against opportunistic infections,Journal of Medicinal Chemistry,1996年,Vol.39, No.7,p.1452-1462
Attorney, Agent or Firm:
Mitsuo Tanaka
Aoyama Aoi
Mitsutaka Iwasaki
Aoyama Aoi
Mitsutaka Iwasaki