Title:
グルコース利用を刺激する化合物および使用方法
Document Type and Number:
Japanese Patent JP4674046
Kind Code:
B2
Abstract:
The invention provides novel compounds of the Formula (I) that stimulate rates of glucose oxidation in myocardial cells wherein W, Cyc, p, , X, Z, R, K-, R, R<1>, R<2>, R<3>,R<4>,< >I and n are as defined for Formula (I) herein. The invention also relates to pharmaceutical compositions comprising compounds capable of stimulation of glucose Oxidation, methods for increasing glucose oxidation rates in myocardial cells, and methods of treatment of myocardial ischemia.
Inventors:
Ropa Chuck, Garry David
Bederas, John Christopher
Dyke, Jason Roland
Bederas, John Christopher
Dyke, Jason Roland
Application Number:
JP2003580269A
Publication Date:
April 20, 2011
Filing Date:
March 31, 2003
Export Citation:
Assignee:
The Governor's of the University of Alberta
International Classes:
A61K31/215; A61K31/13; A61K31/164; A61K31/216; A61K31/25; A61P3/08; A61P3/10; A61P7/08; A61P9/04; A61P9/08; A61P9/10; C07C69/74; C07C69/753; C07C69/757; C07C217/08; C07C219/12; C07C233/60; C07C233/63; A61J1/03; A61J1/14; A61K31/16; A61K31/198; C07C69/003; C07C219/08
Domestic Patent References:
| JP62292788A | ||||
| JP63045252A | ||||
| JP63258840A | ||||
| JP4338379A | ||||
| JP4506902A | ||||
| JP5221945A | ||||
| JP8176080A | ||||
| JP9003016A | ||||
| JP11514331A | ||||
| JP2000510826A | ||||
| JP2002508348A |
Foreign References:
| US0805704 | ||||
| US3306727 | ||||
| US3957849 | ||||
| US4000315 |
Other References:
Journal of Agricultural and Food Chemistry,1976年,24(5),p.1023-1029
Journal of Medicinal Chemistry ,1969年,12,p.923-925
Journal of Medicinal Chemistry ,1994年,37(15),p.2285-2291
Journal of Medicinal Chemistry,1968年,11(6),p.1190-1201
,Journal of the American Chemical Society,2002年,124(9),1856-1857
Journal of Organic Chemistry,1995年,60(14),4314-15
,Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999),1993年,(4),741-8
Journal of Medicinal Chemistry ,1969年,12,p.923-925
Journal of Medicinal Chemistry ,1994年,37(15),p.2285-2291
Journal of Medicinal Chemistry,1968年,11(6),p.1190-1201
,Journal of the American Chemical Society,2002年,124(9),1856-1857
Journal of Organic Chemistry,1995年,60(14),4314-15
,Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999),1993年,(4),741-8
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita