Title:
CONTRACEPTIVE COMPOSITIONS AND METHODS FOR IMPROVED EFFICACY AND MODULATION OF SIDE EFFECTS
Document Type and Number:
Japanese Patent JP2021169503
Kind Code:
A
Abstract:
To provide a contraceptive composition for internal administration to a woman who is at risk of becoming pregnant and a method of contraception by administering the composition.SOLUTION: A contraceptive composition for internal administration to a woman who is at risk of becoming pregnant comprises (a) a progestin with binding affinity to sex hormone binding globulin (SHBG) and (b) one or more non-progestin SHBG ligands that bind to SHBG in an amount sufficient to displace at least a portion of the progestin bound to SHBG, thereby increasing the amount of unbound progestin circulating in the blood plasma of the woman. Here, if the non-progestin SHBG ligand is an estrogen, then the composition is formulated to deliver less than 10 μg of the estrogen per day. A method of contraception comprises internally administering the composition to a woman who is at risk of becoming pregnant.SELECTED DRAWING: Figure 1
Inventors:
AGIS KYDONIEUS
MICHAEL E KAFRISSEN
KATIE MACFARLANE
MICHAEL E KAFRISSEN
KATIE MACFARLANE
Application Number:
JP2021117119A
Publication Date:
October 28, 2021
Filing Date:
July 15, 2021
Export Citation:
Assignee:
AGILE THERAPEUTICS INC
International Classes:
A61K31/565; A61K9/20; A61K9/48; A61K9/70; A61K31/567; A61K39/395; A61K45/00; A61P15/18
Domestic Patent References:
| JP2007524648A | 2007-08-30 |
Attorney, Agent or Firm:
Norihito Yamao
Yasushi Ochiai
Yasushi Ochiai