Title:
Control of the whole body energy homeostasis by regulation of a microRNA
Document Type and Number:
Japanese Patent JP6177243
Kind Code:
B2
Abstract:
The disclosure provides a method of regulating fatty acid or glucose metabolism in a cell by contacting the cell with a modulator of miR-208a and/or miR-208b activity or expression. The disclosure also provides a method of treating or preventing a metabolic disorder, such as obesity, diabetes, or metabolic syndrome, in a subject by administering to the subject an inhibitor of miR-208a and/or miR-208b activity or expression. Also provided is a method of enhancing or improving mitochondrial function and/or redox-homeostasis in a subject by administering to the subject an inhibitor of miR-208a and/or miR-208b activity or expression.
Inventors:
Roy, Eva Van
Eric Olson
Grouter, chad
Rusty, Montgomery
Eric Olson
Grouter, chad
Rusty, Montgomery
Application Number:
JP2014534825A
Publication Date:
August 09, 2017
Filing Date:
October 09, 2012
Export Citation:
Assignee:
Miragen Therapeutics, Incorporated
The Board of Regents, The University of Texas System
The Board of Regents, The University of Texas System
International Classes:
A61K48/00; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P13/12
Domestic Patent References:
| JP2010535246A | ||||
| JP2009545615A |
Other References:
中鎖アシル-CoAデヒドロゲナーゼ欠損症 Medium-chain acyl-CoA dehydrogenase (MCAD)deficiency、日本臨床(増刊)ミトコンドリアとミトコンドリア病、2002, Vol60, Suppl4, p722-725
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto