Title:
ガンマセクレターゼの架橋N-環状スルホンアミド阻害剤
Document Type and Number:
Japanese Patent JP2009506988
Kind Code:
A
Abstract:
The invention provides N-bicyclic sulfonamido compounds of Formula (I) wherein A is as described in the specification and R1 and R2 combine to form a [3.3.1] or a [3.2.1] ring system. Compounds of Formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's Disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders, such as Alzheimer's disease.
Inventors:
Bowers, Simeon
Garofalo, Albert, W.
Hom, Roy, Kay.
Conrad, Andrey, W.
Mattson, Matthew, N.
Nisel, Martin, Elle.
Semco, Christopher, M.
Chuon, Anne, Pee.
Wu, Jin
Shoe, in-two
Garofalo, Albert, W.
Hom, Roy, Kay.
Conrad, Andrey, W.
Mattson, Matthew, N.
Nisel, Martin, Elle.
Semco, Christopher, M.
Chuon, Anne, Pee.
Wu, Jin
Shoe, in-two
Application Number:
JP2008527207A
Publication Date:
February 19, 2009
Filing Date:
August 18, 2006
Export Citation:
Assignee:
Elan Pharmaceuticals, Inc.
International Classes:
C07D471/18; A61K31/439; A61K31/444; A61K31/4995; A61K31/529; A61K31/547; A61P25/28; A61P43/00; C07D487/22; C07D498/18; C07D513/18
Domestic Patent References:
| JP2004532854A | 2004-10-28 | |||
| JPH01132585A | 1989-05-25 |
Foreign References:
| WO2004101562A2 | 2004-11-25 | |||
| EP1118612A1 | 2001-07-25 |
Other References:
JPN6012018504; ＣＨＡＫＩ，Ｈ． ｅｔ ａｌ: 'Ｄｅｓｉｇｎ ａｎｄ ｓｙｎｔｈｅｓｉｓ ｏｆ ４-（ａｃｙｌａｍｉｎｏ）ｐｙｒｉｄｉｎｅ ｄｅｒｉｖａｔｉｖｅｓ： ｎｏｖｅｌ ｈｉｇｈ ａｆｆｉｎｉｔｙ ｃｈｏｌｉｎｅ ｕｐｔａｋｅ ｅｎｈａｎｃ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．５， Ｎｏ．１４, 1995, ｐ．１４９５-１５００
JPN6012018491; ＣＯＸ，Ｐ． ｅｔ ａｌ: '４-（Ｐｈｅｎｙｌｓｕｌｆｏｎｙｌ）-４-ｌｉｔｈｉｏｃｙｃｌｏｐｅｎｔｅｎｅ ａｓ ａ ｎｕｃｌｅｏｐｈｉｌｉｃ ２-ｐｅｎｔｅｎｅ-１，５-ｄｉａｌ ｓｙｎｔｈｅｔｉｃ ｅｑｕｉｖａｌｅｎｔ． Ａ' Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｖｏｌ．４６， Ｎｏ．２７, 2005, ｐ．４６８７-４６９０
JPN6012018493; ＮＯＧＵＣＨＩ，Ｍ． ｅｔ ａｌ: 'Ｍｅｃｈａｎｉｓｔｉｃ ｃｏｎｓｉｄｅｒａｔｉｏｎｓ ｏｎ ｔｈｅ ａｚｅｐｉｎｅ-ｒｉｎｇ ｆｏｒｍａｔｉｏｎ ｔｈｒｏｕｇｈ ｔｈｅ ｅｎｅ ｒｅａｃｔｉｏｎｓ ａｔ ｔｈｅ ｐｅｒｉｐｈｅｒｙ' Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．５２， Ｎｏ．４１, 1996, ｐ．１３０９７-１３１１０
JPN6012018495; ＳＣＨＩＮＫ，Ｈ．Ｅ． ｅｔ ａｌ: 'Ｓｔｅｒｅｏｃｏｎｔｒｏｌｌｅｄ ｅｐｏｘｉｄａｔｉｏｎｓ ｏｆ ｃｙｃｌｏｈｅｐｔｅｎｅ ｄｅｒｉｖａｔｉｖｅｓ ｉｎ ｔｈｅ ｐａｌｌａｄｉｕｍ-ｃａｔａｌｙｚｅｄ ｒｏｕｔｅ ｔｏ ｔｒｏｐａｎ' Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５６， Ｎｏ．８, 1991, ｐ．２７６９-２７７４
JPN6012018497; ＤＯＮＮＩＮＩ，Ｃ．Ｐ． ｅｔ ａｌ: 'Ｄｉｅｌｓ-Ａｌｄｅｒ ｒｅａｃｔｉｏｎｓ ｏｆ ｐｙｒｒｏｌｅｓ ａｓ ａｎ ｅｎｔｒｙ ｔｏ ｓｕｂｓｔｉｔｕｔｅｄ ３-ｏｘａｔｒｏｐａｎｅｓ ａｎｄ ｔｅｔｒａｓｕｂｓｔｉｔｕｔｅｄ ｐｙｒｒ' Ｊｏｕｒｎａｌ ｏｆ Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１４， Ｎｏ．８, 1977, ｐ．１４２３-１４２５
JPN6012018499; ＷＩＥＣＨＭＡＮＮ，Ｍ．: 'Ｓｃｏｐｅ ａｎｄ ｌｉｍｉｔａｔｉｏｎｓ ｏｆ ｔｈｅ ａｎａｌｙｔｉｃａｌ ｕｓｅ ｏｆ ｄａｎｓｙｌ ｃｈｌｏｒｉｄｅ． Ｉ． Ｔｈｅ ｒｅａｃｔｉｏｎ ｏｆ ａｒｏｍａｔｉｃ ｓｕｌｆｏｎ' Ｈｏｐｐｅ-Ｓｅｙｌｅｒ'ｓ Ｚｅｉｔｓｃｈｒｉｆｔ ｆｕｅｒ Ｐｈｙｓｉｏｌｏｇｉｓｃｈｅ Ｃｈｅｍｉｅ Ｖｏｌ．３５８， Ｎｏ．８, 1977, ｐ．９６７-９８０
JPN6012018502; ＰＯＲＴＭＡＮＮ，Ｒ．Ｅ． ｅｔ ａｌ: 'Ｈｅｔｅｒｏｔｒｉｃｙｃｌｏｄｅｃａｎｅ． ＸＶＩ． ２-Ｏｘａ-６-ａｚａａｄａｍａｎｔａｎｅ ａｎｄ ｄｅｒｉｖａｔｉｖｅｓ' Ｈｅｌｖｅｔｉｃａ Ｃｈｉｍｉｃａ Ａｃｔａ Ｖｏｌ．５６， Ｎｏ．６, 1973, ｐ．１９６２-１９８５
JPN6012018491; ＣＯＸ，Ｐ． ｅｔ ａｌ: '４-（Ｐｈｅｎｙｌｓｕｌｆｏｎｙｌ）-４-ｌｉｔｈｉｏｃｙｃｌｏｐｅｎｔｅｎｅ ａｓ ａ ｎｕｃｌｅｏｐｈｉｌｉｃ ２-ｐｅｎｔｅｎｅ-１，５-ｄｉａｌ ｓｙｎｔｈｅｔｉｃ ｅｑｕｉｖａｌｅｎｔ． Ａ' Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｖｏｌ．４６， Ｎｏ．２７, 2005, ｐ．４６８７-４６９０
JPN6012018493; ＮＯＧＵＣＨＩ，Ｍ． ｅｔ ａｌ: 'Ｍｅｃｈａｎｉｓｔｉｃ ｃｏｎｓｉｄｅｒａｔｉｏｎｓ ｏｎ ｔｈｅ ａｚｅｐｉｎｅ-ｒｉｎｇ ｆｏｒｍａｔｉｏｎ ｔｈｒｏｕｇｈ ｔｈｅ ｅｎｅ ｒｅａｃｔｉｏｎｓ ａｔ ｔｈｅ ｐｅｒｉｐｈｅｒｙ' Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．５２， Ｎｏ．４１, 1996, ｐ．１３０９７-１３１１０
JPN6012018495; ＳＣＨＩＮＫ，Ｈ．Ｅ． ｅｔ ａｌ: 'Ｓｔｅｒｅｏｃｏｎｔｒｏｌｌｅｄ ｅｐｏｘｉｄａｔｉｏｎｓ ｏｆ ｃｙｃｌｏｈｅｐｔｅｎｅ ｄｅｒｉｖａｔｉｖｅｓ ｉｎ ｔｈｅ ｐａｌｌａｄｉｕｍ-ｃａｔａｌｙｚｅｄ ｒｏｕｔｅ ｔｏ ｔｒｏｐａｎ' Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５６， Ｎｏ．８, 1991, ｐ．２７６９-２７７４
JPN6012018497; ＤＯＮＮＩＮＩ，Ｃ．Ｐ． ｅｔ ａｌ: 'Ｄｉｅｌｓ-Ａｌｄｅｒ ｒｅａｃｔｉｏｎｓ ｏｆ ｐｙｒｒｏｌｅｓ ａｓ ａｎ ｅｎｔｒｙ ｔｏ ｓｕｂｓｔｉｔｕｔｅｄ ３-ｏｘａｔｒｏｐａｎｅｓ ａｎｄ ｔｅｔｒａｓｕｂｓｔｉｔｕｔｅｄ ｐｙｒｒ' Ｊｏｕｒｎａｌ ｏｆ Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１４， Ｎｏ．８, 1977, ｐ．１４２３-１４２５
JPN6012018499; ＷＩＥＣＨＭＡＮＮ，Ｍ．: 'Ｓｃｏｐｅ ａｎｄ ｌｉｍｉｔａｔｉｏｎｓ ｏｆ ｔｈｅ ａｎａｌｙｔｉｃａｌ ｕｓｅ ｏｆ ｄａｎｓｙｌ ｃｈｌｏｒｉｄｅ． Ｉ． Ｔｈｅ ｒｅａｃｔｉｏｎ ｏｆ ａｒｏｍａｔｉｃ ｓｕｌｆｏｎ' Ｈｏｐｐｅ-Ｓｅｙｌｅｒ'ｓ Ｚｅｉｔｓｃｈｒｉｆｔ ｆｕｅｒ Ｐｈｙｓｉｏｌｏｇｉｓｃｈｅ Ｃｈｅｍｉｅ Ｖｏｌ．３５８， Ｎｏ．８, 1977, ｐ．９６７-９８０
JPN6012018502; ＰＯＲＴＭＡＮＮ，Ｒ．Ｅ． ｅｔ ａｌ: 'Ｈｅｔｅｒｏｔｒｉｃｙｃｌｏｄｅｃａｎｅ． ＸＶＩ． ２-Ｏｘａ-６-ａｚａａｄａｍａｎｔａｎｅ ａｎｄ ｄｅｒｉｖａｔｉｖｅｓ' Ｈｅｌｖｅｔｉｃａ Ｃｈｉｍｉｃａ Ａｃｔａ Ｖｏｌ．５６， Ｎｏ．６, 1973, ｐ．１９６２-１９８５
Attorney, Agent or Firm:
Seiji Ohno
Koji Morita
Reiko Tanaka
Ken Kitano
Natsuki Ito
Koji Morita
Reiko Tanaka
Ken Kitano
Natsuki Ito