To obtain the novel subject compound which is useful for the treatment of arthritis as a matrix metal proteinase inhibitor or a tumor necrosis factor production inhibitor.
This compound is represented by formula I {the broken line represents an arbitrary double bond; n is 0, 1, 2; p is 0 or 1; q is 0, 1, 2; X, Y, Z are each CR1R2 [R1 and R2 are each H, a (substituted) 1-6C alkyl]; Ar is a 6-10 aryl, a 5-9 heteroaryl}, typically N-hydroxy-3-(4-phenoxy- benzenesulfonyl)-bicycle[2, 2.,2]octance-2-carboxamide. In order to this compound, for example, an arylsulfonyl chloride of formula II is allowed to react with sodium iodide in an aprotic solvent such as acetone at room temperature for about 12-18 hours to convert to the corresponding sodium arylsulfinate.
| JP2005343906 | IMPROVED TREATMENT OF MIGRAINE HEADACHE |
| JPS63253014 | MELANIN INHIBITOR |
| WO/1997/043241 | SUBSTITUTED ETHYLENE COMPOUNDS AND DRUGS |
RIZZI JAMES P
RAWSON DAVID J
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