Title:
システイン改変フィブロネクチンＩＩＩ型ドメイン結合分子
Document Type and Number:
Japanese Patent JP6585040
Kind Code:
B2
Abstract:
Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizing a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules; and recovering the cysteine engineered FN3 domain containing molecule. Isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically.
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Inventors:
Goldberg, Shalom
Jacobs, Stephen
Lynn, Tricia
O'Neill, Carin
Jacobs, Stephen
Lynn, Tricia
O'Neill, Carin
Application Number:
JP2016522781A
Publication Date:
October 02, 2019
Filing Date:
October 13, 2014
Export Citation:
Assignee:
Janssen Biotech, Inc.
International Classes:
C12N15/09; C07K14/78; C12P21/02
Domestic Patent References:
| JP2011507543A | ||||
| JP2011517314A | ||||
| JP2011522517A | ||||
| JP2011520961A |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Junko Kobayashi
Norio Omori
Tomohiro Maruyama
Yasuhito Suzuki
Eiji Katayama
Junko Kobayashi
Norio Omori
Tomohiro Maruyama
Yasuhito Suzuki