Title:
CYTOTOXIC MATTER CONTAINING NEW POTENT TAXANE AND THERAPEUTIC USE THEREOF
Document Type and Number:
Japanese Patent JP2010106040
Kind Code:
A
Abstract:
To provide new cytotoxic matter to induce a cell death in a selected cell population.
The new cytotoxic matter includes new taxanes of 2'(3'-dephenyl-3'-(isobutenyl)-7-(methyldisulphanyl-propanoyl)-docetaxel) or the like which have a binding group at the 7 position. The taxane is chemically combined with cell-binding matter which can make a selected cell population a target [an antibody or its fragment (especially monoclonal antibody), lymphokine, hormone, growth factor, vitamin, nutrition delivery molecule (for example, transferrin) or the like] through the 7 position bondage, whereby the taxane is delivered to a selected cell population in a targeting style, and therefore, the new cytotoxic matter has a selective treating application.
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Inventors:
BALOGLU ERKAN
MILLER MICHAEL
CHARI RAVI V J
MILLER MICHAEL
CHARI RAVI V J
Application Number:
JP2010004372A
Publication Date:
May 13, 2010
Filing Date:
January 12, 2010
Export Citation:
Assignee:
IMMUNOGEN INC
International Classes:
C07D305/14; A61K31/337; A61P1/16; A61P9/00; A61P11/00; A61P13/12; A61P19/02; A61P25/00; A61P29/00; A61P31/00; A61P31/04; A61P31/12; A61P31/18; A61P33/00; A61P33/10; A61P33/12; A61P35/00; A61P37/02; A61P37/04; A61P37/06; A61P43/00; C07D407/12; C07D407/14; C07D409/12; A61K47/42; A61K47/48
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Ken Matsumoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Ken Matsumoto
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