Title:
STABILIZATION OF RADIOPHARMACEUTICAL LABELED WITH 18F
Document Type and Number:
Japanese Patent JP2010106041
Kind Code:
A
Abstract:
To provide an 18F isotope-labeled FDG ([18F]2-Fluoro-2-Deoxy-D-glucose (hereinafter FDG)), radiopharmaceutical which is stable and safety to human body.
The 18F isotope-labeled FDG radiopharmaceutical is stabilized against degradation in radiochemical purity due to radiolysis using selected amounts of ethyl alcohol that depend on the activity concentration of the 18F, considering the limits set by various pharmacopoeia standards. Any of the well-known production methods for the FDG may be used and ethyl alcohol maybe added at several stages, preferably as part of the standard hydrolysis step. The particular radiopharmaceutical is used extensively in diagnostic imaging by the Positron Emission Tomography technique.
Inventors:
KISELEV MAXIM Y
VINCENT TADINO
VINCENT TADINO
Application Number:
JP2010005640A
Publication Date:
May 13, 2010
Filing Date:
January 14, 2010
Export Citation:
Assignee:
ION BEAM APPLIC SA
International Classes:
A61K51/00; C07H5/02
Domestic Patent References:
| JPH09263590A | 1997-10-07 | |||
| JPH09263591A | 1997-10-07 | |||
| JPH09263592A | 1997-10-07 | |||
| JPH09263593A | 1997-10-07 | |||
| JPH09263594A | 1997-10-07 |
Other References:
JPN6009008217; アイソトープトレーサ法入門 , 1993, ３８頁, 学会出版センター
JPN6009008219; 化学・生化学のための放射化学入門 , 1989, １４９頁, 学会出版センター
JPN6009008220; 放射線概論 第１種放射線試験受験用テキスト , 1996, ２２５頁, 通商産業研究社
JPN6009008222; ラジオアイソトープ薬物代謝実験法 , 1981, １０９頁, 丸善
JPN6009008224; アイソトープ協会教務課: Ｉｓｏｔｏｐｅ ｎｅｗｓ , 1979, ２８頁
JPN6009008219; 化学・生化学のための放射化学入門 , 1989, １４９頁, 学会出版センター
JPN6009008220; 放射線概論 第１種放射線試験受験用テキスト , 1996, ２２５頁, 通商産業研究社
JPN6009008222; ラジオアイソトープ薬物代謝実験法 , 1981, １０９頁, 丸善
JPN6009008224; アイソトープ協会教務課: Ｉｓｏｔｏｐｅ ｎｅｗｓ , 1979, ２８頁
Attorney, Agent or Firm:
Yoshiharu Shirahama
Shuji Shirahama
Kajita Eri
Shuji Shirahama
Kajita Eri