Title:
PPARアゴニスト活性を有する誘導体
Document Type and Number:
Japanese Patent JP4199298
Kind Code:
B2
Abstract:
A compound of the formula (I):
a pharmaceutically acceptable salt or solvate thereof, wherein
Ring Q is optionally substituted monocyclic aryl, optionally substituted monocyclic heteroaryl, optionally substituted fused aryl or optionally substituted fused heteroaryl,
Y 1 is a bond or -NR 6 - or the like,
Ring A is optionally substituted nonaromatic heterocyclediyl,
a group of the formula: -Y 2 Z 1 - is a group of the formula:
or
R 7 are each independently hydrogen, optionally substituted lower alkyl or the like,
R 8 and R 9 are each independently hydrogen or optionally substituted lower alkyl,
n is an integer between 1 and 3,
Z 1 is a bond, -O-, -S- or -NR 9 -,
Ring B is optionally substituted aromatic carbocyclediyl or optionally substituted aromatic heterocyclediyl,
Y 3 is a bond, optionally substituted lower alkylene optionally intervened by -O-, optionally substituted lower alkenylene or the like, and
Z 2 is COOR 3 or the like.
Inventors:
Akiko Itai
Susumu Muto
Ryuko Tokuyama
Hiroshi Fukasawa
Takafumi Ohara
Terukazu Kato
Susumu Muto
Ryuko Tokuyama
Hiroshi Fukasawa
Takafumi Ohara
Terukazu Kato
Application Number:
JP2008061970A
Publication Date:
December 17, 2008
Filing Date:
March 12, 2008
Export Citation:
Assignee:
Pharmaceutical Molecular Design Laboratory Co., Ltd.
Shionogi Pharmaceutical Co., Ltd.
Shionogi Pharmaceutical Co., Ltd.
International Classes:
C07D241/04; A61K31/495; A61K31/496; A61K31/498; A61P1/04; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P5/14; A61P5/50; A61P9/10; A61P9/12; A61P13/12; A61P15/08; A61P17/06; A61P19/02; A61P19/10; A61P25/00; A61P25/16; A61P25/28; A61P29/00; A61P35/00; A61P37/08; A61P43/00; C07D401/04; C07D403/04; C07D405/04; C07D409/04; C07D413/04; C07D417/04; C07D513/04
Domestic Patent References:
| JP2007532563A | ||||
| JP2007513969A | ||||
| JP2006298925A |
Foreign References:
| WO2005121094A1 |
Attorney, Agent or Firm:
Kenichi Sugita
Hiromitsu Takayama
Hiromitsu Takayama