Title:
重水素化化合物及びその医薬的用途
Document Type and Number:
Japanese Patent JP7050336
Kind Code:
B2
Abstract:
The present disclosure relates to a compound of Formula I or a non-toxic pharmaceutically acceptable salt thereof, wherein each R1, R2, R3, and R4 is independently selected from methyl (-CH) and trideuteromethyl (-CD), at least one of R1, R2, R3, and R4 is selected from trideuteromethyl (-CD).The compound is a deuterated derivative of L-tetrahydropalmatine, which not only markedly improves pharmacological effects, but also significantly reduces cardiac side effects, liver toxicity, and remarkably decreases individual differences.
Inventors:
Naka Hana
Kenmei Wang
Jin Snow Peak
Kenmei Wang
Jin Snow Peak
Application Number:
JP2019541837A
Publication Date:
April 08, 2022
Filing Date:
September 22, 2017
Export Citation:
Assignee:
Taizhou Huayuan Pharmaceutical Technology Co., Ltd.
International Classes:
A61K31/4375; C07D455/03; A61P25/04; A61P25/18; A61P25/32; A61P25/34; A61P25/36; A61P27/00; A61P35/00
Domestic Patent References:
| JP2012503010A |
Foreign References:
| KR1020100064512A |
Other References:
GONG, X et al.,Levo-tetrahydropalmatine, a natural, mixed dopamine receptor antagonist, inhibits methamphetamine self-administration and methamphetamine-induced reinstatement,Pharmacology, Biochemistry and Behavior,2016年01月12日,Vol. 144,pp. 67-72
RICHTER, WJ et al.,Detection of 9-Methoxy SUbstitution in Tetrahydroprotoberberine Alkaloids by Mass Spectrometry,Helvetica Chimica Acta,1975年,Vol. 58,pp. 203-209
RICHTER, WJ et al.,Detection of 9-Methoxy SUbstitution in Tetrahydroprotoberberine Alkaloids by Mass Spectrometry,Helvetica Chimica Acta,1975年,Vol. 58,pp. 203-209
Attorney, Agent or Firm:
Patent business corporation HARAKENZO WORLD PATENT & TRADEMARK