抗ROBO1抗体を用いる癌の診断および治療

Japanese Patent JP4913590

B2

A method for diagnosing cancer comprising detecting ROBO1 protein is disclosed. In addition, a method for treating a disease caused by abnormal cell growth comprising administrating an antibody that binds to ROBO1, as well as a pharmaceutical composition, a cell growth inhibitor and an anticancer agent comprising an antibody that binds to ROBO1 as an active ingredient are disclosed. Further, a method for inducing cell damages in a ROBO1 expressing cell and a method for inhibiting the growth of a ROBO1 expressing cell by bringing a ROBO1 expressing cell into contact with an antibody that binds to ROBO1, are disclosed. Furthermore, a method for monitoring progression of hepatitis by detecting ROBO1 protein is disclosed.

WO/2010/134073	KITS FOR AND METHODS OF DIFFERENTIAL STAINING OF CERVICAL CANCER CELLS AND/OR TISSUES
WO/2010/034128	SPY1A AS A DIAGNOSTIC AND PROGNOSTIC MARKER OF CANCER
JPH11511962	INDUSTRIAL APPLICABILITY: Macrophage activator derived from cloned vitamin D-binding protein

Hiroyuki Yutani
Brush Takashi
Ryo Watanabe
Fukayama Masahisa
Yukio Ito
Masahiro Arai
Hirotaka Ito
Toshihiko Otomo
Shinichi Funabashi
Kyoko Kinoshita

JP2006511900A

April 11, 2012

March 31, 2005

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Perseus Proteomics Inc.
Chugai Pharmaceutical Co., Ltd.
Hiroyuki Yutani

G01N33/574; A61K39/395; A61P35/00; A61P43/00; C07K16/30; C12N5/07; G01N33/576; C07K14/82; C12N15/02; C12N15/09

WO2003029488A1

Seiji Ohno
Koji Morita
Reiko Tanaka

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