Title:
DIAZABICYCLO DERIVATIVE
Document Type and Number:
Japanese Patent JP3407916
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new diazabicyclo derivative useful as a selective antagonistic agent for 5-hydroxytryptamine (5-HT) in a 5-HT3 receptor.
CONSTITUTION: The objective compound of formula I [R1 is H, alkyl, alkenyl, alkynyl, cycloalkyl, alkoxycarbonyl, acyl, aryl, heteroarylalkyl, arylalkyl, etc.; R2 is H or alkyl; R3 and R4 are H, alkyl, alkenyl, acyl, alkoxyalkyl or arylalkyl, except that R1 is H, alkyl, unsubstituted benzyl or dimethylaminoethyl; R2 is H and R3 and R4 are methyl] or its acid addition salt or quaternary ammonium salt, e.g. endo-3,9-dimethyl-3,9-diazabicyclo[3.3.1]non-7-yl-1-allylindazole-3- carboxamide. This compound is obtained by reacting an indazole-3-carboxylic acid of formula II with a 3,9-diazabicyclo[3.3.1] non-7-amine derivative of formula III.
Inventors:
Hiroaki Sato
Haruhiko Kikuchi
Kazuhiko Yamada
Ryuta Fukutomi
Masashi Suzuki
Koichiro Hagiwara
Toru Hayakawa
Takeo Arai
Setsuko Mino
Haruhiko Kikuchi
Kazuhiko Yamada
Ryuta Fukutomi
Masashi Suzuki
Koichiro Hagiwara
Toru Hayakawa
Takeo Arai
Setsuko Mino
Application Number:
JP1301393A
Publication Date:
May 19, 2003
Filing Date:
January 29, 1993
Export Citation:
Assignee:
Nisshin Pharma Inc.
International Classes:
A61K31/495; A61K31/4995; A61P1/00; A61P1/08; A61P25/00; A61P25/04; A61P25/18; A61P25/24; A61P25/30; A61P43/00; C07D471/08; (IPC1-7): C07D471/08
Domestic Patent References:
JP6501256A |
Other References:
【文献】特許3251954(JP,B2)
Attorney, Agent or Firm:
Chika Takagi (2 outside)