Title:
肝前駆細胞から肝細胞への分化促進剤及びその用途
Document Type and Number:
Japanese Patent JPWO2014025046
Kind Code:
A1
Abstract:
本発明は、Dnmt-1の発現を抑制する物質又はDnmt-1の機能を阻害する物質を有効成分として含有する、肝前駆細胞から肝細胞への分化促進剤、及び肝前駆細胞から肝細胞（好ましくは成熟度の高い肝細胞）を製造する方法を提供する。
Inventors:
Takahiro Ochiya
Gayusutsu, Ryuk
Gayusutsu, Ryuk
Application Number:
JP2014529585A
Publication Date:
July 25, 2016
Filing Date:
August 09, 2013
Export Citation:
Assignee:
National Cancer Research Center
ds Pharma Biomedical Co., Ltd.
ds Pharma Biomedical Co., Ltd.
International Classes:
C12N15/09; C12N5/071; C12N5/10; C12N15/113; C12Q1/02
Other References:
INVEST. NEW DRUGS, vol. 30, no. 4, JPN6013051705, 29 March 2011 (2011-03-29), pages 1715 - 1724
BMC GENOMICS, vol. 7, no. 181, JPN6013051706, 19 July 2006 (2006-07-19), pages 1 - 12
WORLD J. GASTROENTEROL., vol. 15, no. 16, JPN6013051707, 28 April 2009 (2009-04-28), pages 2020 - 2026
INVEST. NEW DRUGS, vol. 30, no. 4, JPN6013051705, 29 March 2011 (2011-03-29), pages 1715 - 1724
BMC GENOMICS, vol. 7, no. 181, JPN6013051706, 19 July 2006 (2006-07-19), pages 1 - 12
WORLD J. GASTROENTEROL., vol. 15, no. 16, JPN6013051707, 28 April 2009 (2009-04-28), pages 2020 - 2026
HEPATOLOGY, vol. 58, no. 3, JPN6013051709, 30 July 2013 (2013-07-30), pages 1153 - 1165
HEPATOLOGY, vol. Vol.56, Suppl.1, JPN6013051710, October 2012 (2012-10-01), pages p.796A
PLOS ONE, vol. Vol.7, No.4, e35331, JPN6013051708, 9 April 2012 (2012-04-09), pages 1 - 12
HEPATOLOGY, vol. 51, no. 3, JPN6017021727, March 2010 (2010-03-01), pages 881 - 890
HEPATOLOGY, vol. 58, no. 3, JPN6013051709, 30 July 2013 (2013-07-30), pages 1153 - 1165
HEPATOLOGY, vol. Vol.56, Suppl.1, JPN6013051710, October 2012 (2012-10-01), pages p.796A
PLOS ONE, vol. Vol.7, No.4, e35331, JPN6013051708, 9 April 2012 (2012-04-09), pages 1 - 12
HEPATOLOGY, vol. 51, no. 3, JPN6017021727, March 2010 (2010-03-01), pages 881 - 890
BMC GENOMICS, vol. 7, no. 181, JPN6013051706, 19 July 2006 (2006-07-19), pages 1 - 12
WORLD J. GASTROENTEROL., vol. 15, no. 16, JPN6013051707, 28 April 2009 (2009-04-28), pages 2020 - 2026
INVEST. NEW DRUGS, vol. 30, no. 4, JPN6013051705, 29 March 2011 (2011-03-29), pages 1715 - 1724
BMC GENOMICS, vol. 7, no. 181, JPN6013051706, 19 July 2006 (2006-07-19), pages 1 - 12
WORLD J. GASTROENTEROL., vol. 15, no. 16, JPN6013051707, 28 April 2009 (2009-04-28), pages 2020 - 2026
HEPATOLOGY, vol. 58, no. 3, JPN6013051709, 30 July 2013 (2013-07-30), pages 1153 - 1165
HEPATOLOGY, vol. Vol.56, Suppl.1, JPN6013051710, October 2012 (2012-10-01), pages p.796A
PLOS ONE, vol. Vol.7, No.4, e35331, JPN6013051708, 9 April 2012 (2012-04-09), pages 1 - 12
HEPATOLOGY, vol. 51, no. 3, JPN6017021727, March 2010 (2010-03-01), pages 881 - 890
HEPATOLOGY, vol. 58, no. 3, JPN6013051709, 30 July 2013 (2013-07-30), pages 1153 - 1165
HEPATOLOGY, vol. Vol.56, Suppl.1, JPN6013051710, October 2012 (2012-10-01), pages p.796A
PLOS ONE, vol. Vol.7, No.4, e35331, JPN6013051708, 9 April 2012 (2012-04-09), pages 1 - 12
HEPATOLOGY, vol. 51, no. 3, JPN6017021727, March 2010 (2010-03-01), pages 881 - 890
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Murata Miyuki
Junzo Koike
Hirofumi Toma
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Murata Miyuki
Junzo Koike
Hirofumi Toma