Title:
DIPHENHYDRAMINE-ACESULFAME ADDUCT, METHOD FOR PRODUCING THE SAME AND ORAL PREPARATION CONTAINING THE ADDUCT
Document Type and Number:
Japanese Patent JP2009007311
Kind Code:
A
Abstract:
To obtain a new diphenhydramine derivative that has a pharmacological activity as an antihistaminic agent and a sleep-introducing agent and alleviated bitterness; to provide a method for producing the same; and to obtain an oral preparation composed of the diphenhydramine derivative as an active ingredient.
The diphenhydramine-acesulfame adduct has a structure represented by formula (I). The method for producing the adduct includes bringing a diphenhydramine cation-containing water-soluble salt into contact with an acesulfame anion-containing water-soluble salt in a water-based medium. The oral preparation contains the adduct.
Inventors:
SUZUKI EIJI
SUGIURA YUSAKU
KATA AKIO
SUGIURA YUSAKU
KATA AKIO
Application Number:
JP2007171818A
Publication Date:
January 15, 2009
Filing Date:
June 29, 2007
Export Citation:
Assignee:
LINTEC CORP
ZERIA PHARM CO LTD
ZERIA PHARM CO LTD
International Classes:
C07C217/10; A61K31/135; A61K31/54; A61K47/22; A61P25/20; A61P43/00; C07D291/06
Domestic Patent References:
| JP2004527491A | 2004-09-09 | |||
| JP2006524675A | 2006-11-02 | |||
| JP2004515478A | 2004-05-27 |
Foreign References:
| WO2005117895A2 | 2005-12-15 | |||
| WO2005094832A1 | 2005-10-13 | |||
| US20020022057A1 | 2002-02-21 |
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto
Hiromi Matoba
Moriya Kataka
Ohno Shiki
Masahiro Matsuda
Tomohisa Suzuki
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto
Hiromi Matoba
Moriya Kataka
Ohno Shiki
Masahiro Matsuda
Tomohisa Suzuki
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