Title:
二重作用性抗高血圧剤
Document Type and Number:
Japanese Patent JP5322309
Kind Code:
B2
Abstract:
The invention is directed to compounds of formula I: wherein Ar, r, R3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula I have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.
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Inventors:
Choi, Sukki
Fathery, Paul Earl.
Hedge, shalas
Hudson, ryan
Jenza, keith
Marquez, Daniel
McKinell, Robert Murray
Vassib
Fathery, Paul Earl.
Hedge, shalas
Hudson, ryan
Jenza, keith
Marquez, Daniel
McKinell, Robert Murray
Vassib
Application Number:
JP2009548306A
Publication Date:
October 23, 2013
Filing Date:
January 31, 2008
Export Citation:
Assignee:
Theravans, Incorporated
International Classes:
C07C259/06; A61K31/145; A61K31/195; A61K31/41; A61K45/00; A61P9/04; A61P9/12; A61P43/00; C07C323/25; C07C323/26; C07C323/29; C07C323/52; C07C323/53; C07C323/56; C07C323/60; C07C327/04; C07D257/04
Domestic Patent References:
| JP2000513750A | ||||
| JP2003520785A | ||||
| JP2002519380A | ||||
| JP7048360A | ||||
| JP4235149A | ||||
| JP2003048874A | ||||
| JP8245385A |
Foreign References:
| EP0498361A1 | ||||
| WO2006086456A1 | ||||
| WO2007056546A1 |
Other References:
DRUG METABOLISM AND DISPOSITION,2007年,Vol.35, No.5,795-805
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita