PURPOSE: To obtain a new propionamide derivative useful as a therapeutic agent and/or preventive for cardiovascular disorder, renal insufficiency, periodic edema, hyperaldosteronemia, hypercalciuria, etc., having inhibitory action on neutral endopeptidase.
CONSTITUTION: A compound of formula I [R1 and R3 are ar(lower)alkyl; R2 is carboxy, hydroxyaminocarbonyl or (protected hydroxy)aminocarbonyl; R4 is carboxy or protected carboxy; A is lower alkylene or cyclo (lower) alkylene] and its salt such as 3-[(2R,3R)-2,3-dibenzyl-3-carboxypropionamido]propionic acid ethyl ester. A compound of Ia (R4a is protected carboxyl) is obtained by reacting a compound of formula II with a compound of formula III or its salt. The compound has inhibitory action on neutral endopeptidase EC3. 4. 24. 11 and is useful for treating and preventing glaucoma, asthma, inflammation, ache, epilepsy, etc.
WO/2011/094544 | NUTRITIONAL EMULSIONS COMPRISING CALCIUM HMB AND SOLUBLE PROTEIN |
JPH0717942 | COMPOUND |
JP2023517997 | A novel nutrient for enhancing load-induced muscle hypertrophy |
Koichi Takimoto
Takenaka Kohei
Takafumi Mitsunaga