Title:
ＥＭＬ４－ＡＬＫ遺伝子変異分析方法
Document Type and Number:
Japanese Patent JP7241422
Kind Code:
B2
Abstract:
According to one embodiment of the present invention, there are provided qRT-PCR primers capable of detecting EML4-ALK gene variant based on circulating tumor cells at a more sensitive detection limit than a conventional method.According to another embodiment of the present invention, there is a lung cancer patient screening method which is capable of detecting EML4-ALK gene variant using circulating tumor cells even in a lung cancer patient on whom ALK-FISH testing has been difficult to perform, due to difficulty in collecting a solid lung cancer tissue sample. Thus, the screening method may determine whether an anticancer drug targeting the EML4-ALK gene variant may be applied to the lung cancer patient.
Inventors:
John, Byung Hee
Application Number:
JP2020504378A
Publication Date:
March 17, 2023
Filing Date:
July 17, 2018
Export Citation:
Assignee:
CYTOGEN, INC.
International Classes:
C12Q1/686; A61K31/4545; A61K45/00; A61P35/00; C12M1/12; C12Q1/24; C12Q1/6851; G01N33/50
Foreign References:
| KR1020160001304A | ||||
| KR101254679B1 | ||||
| KR1020110115478A | ||||
| KR101254680B1 | ||||
| KR101226515B1 | ||||
| WO2017181183A1 |
Other References:
TAN, C. L. et al. ,Concordance of anaplastic lymphoma kinase (ALK) gene rearrangements between circulating tumor cells and tumor in non-small cell lung cancer,Oncotarget,2016年,Vol.7, No.17,P.23251-23262
Attorney, Agent or Firm:
Shin Shin
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