Title:
ENHANCERS OF NOTCH SIGNALING AND THEIR USE IN THE TREATMENT OF CANCERS AND MALIGNANCIES MEDICABLE BY UPREGULATION OF NOTCH
Document Type and Number:
Japanese Patent JP2023002688
Kind Code:
A
Abstract:
To provide a compound which acts as Notch signaling enhancers and which can be used for the treatment of cancers and other diseases which cannot be treated by Notch signaling inhibitors.SOLUTION: There is provided a compound showing the general formula (I) and/or a pharmaceutically acceptable salt thereof, wherein the compound is for the treatment of a disease selected from the group of dermatological disorders including atopic dermatitis, psoriasis, immune related disorders, cancer, squamous cell carcinoma, cutaneous and lung squamous cell carcinoma, head and neck cancer, non-melanoma skin cancer, basal cell carcinoma and actinic keratosis, neuroendocrine tumors, neuroendocrine small cell carcinoma and carcinoid tumors, thyroid carcinomas, muscular disorders, muscular dystrophy, and impaired regeneration capacity after injury; and is for use in immunotherapy for cancer.SELECTED DRAWING: None
Inventors:
Rheinmuller Victoria
Joo Jepin
Joo Jepin
Application Number:
JP2022168148A
Publication Date:
January 10, 2023
Filing Date:
October 20, 2022
Export Citation:
Assignee:
Zenio Pro Gaming Beher
International Classes:
C07C69/92; A61K31/192; A61K31/216; A61K31/44; A61P17/00; A61P17/04; A61P17/06; A61P21/00; A61P21/04; A61P35/00; A61P37/02; A61P37/04; A61P37/08; A61P43/00; C07C65/24; C07D213/80; C07D213/82
Attorney, Agent or Firm:
Masahiro Nanjo
Ayako Seta
Koichiro Inami
Hidemitsu Hara
Ayako Seta
Koichiro Inami
Hidemitsu Hara