To provide a method for treating atherosclerosis regardless of the decrease of lipid.

The progress of atherogenesis lesion is prevented by administrating tamoxifen, 4-hydroxytamoxifen, raloxifene, toremifene, centchroman, idoxifene, 6-(4-hydroxy-phenyl)-5-[4-(2-pyperidin-l-ylethoxy) benzyl]-naphthalen-2-ol or {4-[2-(2-aza-bicyc1o[2.2.1]hept-2-yl)ethoxyl-phenyl}-[6-hydroxy-2-(4-hydroxy- phenyl)-benzo[b]thiophen-3-yl]-methanone, or pharmaceutically acceptable salts thereof in a mammal requiring the treatment of the atherosclerosis, and atherosclerosis is treated by stabilizing plaque regardless of the decrease of lipid.