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Title:
FORSKOLIN DERIVATIVE-CONTAINING ORAL PREPARATION AND PRODUCTION OF MEDICINE PREPARATION
Document Type and Number:
Japanese Patent JPH10147524
Kind Code:
A
Abstract:

To obtain an oral preparation useful for chronic cardiac insufficiency, excellent in shelf stability of a forskolin derivative salt, by using both the forskolin derivative and a specific alkali metal compound.

This oral preparation comprises a forskolin derivative salt and a halogenated alkali metal as medicinal components. A compound of the formula [R1 is H; R4 is vinyl, ethyl or cyclopropyl; one of R2 and R3 is CO (CH2)mNR5R6 (R5 and R6 are each H, an alkyl or R5 and R6 are bonded to form an alkylene; (m) is 1-5) and the other is H or CO(CH2)nX [X is NR7R8 (R7 and R8 are each H, an alkyl, etc.); (n) is 1-5]] is preferable as the forskolin salt. Sodium chloride or potassium chloride is preferable as the halogenated alkali metal. The amount of the halogenated alkali metal is preferably 0.01-26 pts.wt. based on 1 pt.wt. of the forskolin derivative.


Inventors:
KOMURO CHIKARA
YAHIRO TOMIO
YOSHIDA HIROYUKI
Application Number:
JP24753397A
Publication Date:
June 02, 1998
Filing Date:
August 29, 1997
Export Citation:
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Assignee:
NIPPON KAYAKU KK
International Classes:
A61K9/20; A61K31/35; A61K31/352; A61K47/02; A61P9/00; C07D311/92; (IPC1-7): A61K31/35; A61K47/02