Title:
EXPRESSION OF EXOGENEOUS POLYNUCLEOTIDE SEQUENCE IN VERTEBRATE
Document Type and Number:
Japanese Patent JP3683798
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a medicine for a gene therapy and an immunization.
SOLUTION: This medicine for direct administration into the tissue of a body for a therapy or an immunogenic treatment, is non-integrative and non- infectious, and consists of a naked polynucleotide having a sequence for functionally encoding a gene product capable of generating a desired therapeutic effect or immunogenic effect in the body and a cationic lipid substance, wherein the polynucleotide is compounded with the cationic lipid.
Inventors:
Fergner, Philip Elle
Wolf, John Asher
Rhodes, Garry H
Marlown, Robert Wallis
Carson, Dennis A.
Wolf, John Asher
Rhodes, Garry H
Marlown, Robert Wallis
Carson, Dennis A.
Application Number:
JP2000317778A
Publication Date:
August 17, 2005
Filing Date:
March 21, 1990
Export Citation:
Assignee:
Baikal Incorporated
International Classes:
C07H21/04; A61K9/127; A61K31/70; A61K31/7088; A61K35/12; A61K38/00; A61K38/19; A61K38/21; A61K38/22; A61K38/43; A61K39/00; A61K39/395; A61K47/18; A61K47/24; A61K47/48; A61K48/00; A61P31/18; A61P31/20; A61P31/22; A61P35/00; A61P37/02; A61P37/04; A61P43/00; C07K14/16; C07K14/61; C12N9/02; C12N9/10; C12N9/12; C12N9/78; C12N15/09; C12N15/12; C12N15/87; (IPC1-7): A61K48/00; A61K9/127; A61K38/00; A61K38/21; A61K38/22; A61K38/43; A61K39/395; A61K47/18; A61K47/24; A61K47/48; A61P31/18; A61P31/20; A61P31/22; A61P35/00
Domestic Patent References:
| JP2135092A |
Other References:
NICOLAU C. et al,Liposomes as carriers for in vivo gene transfer and expression,Methods Enzymol.,Vol.149,157-176,1987
NICOLAU C.,Liposomes and erythrocytes as drug carriers in vivo,Biochem. Soc. Trans.,Vol.16, No.6,917-921,1988
FELGNER P. L. et al,Lipofection: A hihly efficient, lipid-mediated DNA-transfection procedure,Proc. Natl. Sci. USA,米国,Vol.84,7413-7417
RUPERT L. A. M. et al,Fusogenic Behavior of Didodecyldimethylammonium Bromide Bilayer Vesicles,J. Am. Chem. Soc.,米国,Vol.107, No.9,2628-2631
RUSTEM Y. M. et al,Role of Liposome Type and Route of Administration in the Antitumor Activity of Liposome-entrapped l-,CANCER RESEARCH,米国,Vol.39,1390-1395
Interaction of Cationic Lipid Vesicles with Negatively Charged Phospholipid Vesicles and Biological ,Biochemistry,米国,American Chemical Society,Vol.27, No.11,3917-3925
国武豊喜,合成二分子膜-有機分子の自己組織化,生物物理,日本,Vol.21, No.6,289-301
菊池寛他,リポソーム-基礎と応用-,油化学,日本,Vol.34, No.10,784-798
NICOLAU C.,Liposomes and erythrocytes as drug carriers in vivo,Biochem. Soc. Trans.,Vol.16, No.6,917-921,1988
FELGNER P. L. et al,Lipofection: A hihly efficient, lipid-mediated DNA-transfection procedure,Proc. Natl. Sci. USA,米国,Vol.84,7413-7417
RUPERT L. A. M. et al,Fusogenic Behavior of Didodecyldimethylammonium Bromide Bilayer Vesicles,J. Am. Chem. Soc.,米国,Vol.107, No.9,2628-2631
RUSTEM Y. M. et al,Role of Liposome Type and Route of Administration in the Antitumor Activity of Liposome-entrapped l-,CANCER RESEARCH,米国,Vol.39,1390-1395
Interaction of Cationic Lipid Vesicles with Negatively Charged Phospholipid Vesicles and Biological ,Biochemistry,米国,American Chemical Society,Vol.27, No.11,3917-3925
国武豊喜,合成二分子膜-有機分子の自己組織化,生物物理,日本,Vol.21, No.6,289-301
菊池寛他,リポソーム-基礎と応用-,油化学,日本,Vol.34, No.10,784-798
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama