FIFTEEN-VALENT PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE VACCINE COMPOSITION

Title:

FIFTEEN-VALENT PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE VACCINE COMPOSITION

Document Type and Number:

Japanese Patent JP2014012720

Kind Code:

A

Abstract:

To provide a multivalent immunogenic composition having 15 distinct polysaccharide-protein conjugates, which is effective for prevention of Streptococcus pneumoniae.

Each conjugate consists of a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 22F, 23F, or 33F) conjugated to a carrier protein, preferably CRM197. An immunogenic composition, preferably formulated as a vaccine on an aluminum-based adjuvant, provides broad coverage against pneumococcal disease, particularly in infants and young children.

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Inventors:

MICHAEL J CAULFIELD
PATRICK L AHL
JEFFREY T BLUE
JAYME L CANNON

Application Number:

JP2013189954A

Publication Date:

January 23, 2014

Filing Date:

September 13, 2013

Export Citation:

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Assignee:

MERCK SHARP & DOHME

International Classes:

A61K39/09; A61K39/00; A61K39/385; A61K39/39; A61K47/42; A61K47/48; A61P31/04

Domestic Patent References:

JP2008535838A	2008-09-04
JP2009520759A	2009-05-28
JP2009173681A	2009-08-06

Attorney, Agent or Firm:

Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama

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