Title:
FLUOROPOLYMER-BASED EMULSION FOR INTRAVENOUS DELIVERY OF VOLATILE FLUORIDATED ANESTHETIC
Document Type and Number:
Japanese Patent JP2014144954
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a therapeutic formulation such as therapeutic emulsion and nano emulsion, and a relevant method for delivery of a therapeutic fluoridated compound such as an important class of per-fluoridated and/or per-halogenated volatile anesthetic with a low boiling point.SOLUTION: An emulsion-based volatile fluoridated anesthetic formulation suitable for intravenous administration allows delivery and release of a volatile fluoridated anesthetic compound in an amount effective for introduction and maintenance of an anesthesia in a patient. By intravenous delivery of the emulsion-based volatile fluoridated anesthetic formulation, the in vivo anesthesia level in a patient can be selectively modulated very rapidly and accurately without needing to give excessive ventilation to the patient or without using a stimulus agent. A therapeutic formulation comprises a semi-fluoridated block polymer having a hydrophilic block and a pro-fluoro block, a therapeutic fluoridated compound, a stabilization additive agent, and an aqueous solution.
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Inventors:
SANDRO MECOZZI
ROBERT A PEARCE
JONATHAN P FAST
ROBERT A PEARCE
JONATHAN P FAST
Application Number:
JP2014011369A
Publication Date:
August 14, 2014
Filing Date:
January 24, 2014
Export Citation:
Assignee:
WISCONSIN ALUMNI RES FOUND
International Classes:
A61K47/34; A61K31/08; A61P25/02
Foreign References:
| WO2005067517A2 | 2005-07-28 |
Attorney, Agent or Firm:
Yamada Koichi
Noda Masakazu
Ikeda Adult
Noda Masakazu
Ikeda Adult