FREEZE-DRIED OR SEDIMENTED CEPHALOSPORIN ZWITTER ION AND SALT BONDED BODY

Title:

FREEZE-DRIED OR SEDIMENTED CEPHALOSPORIN ZWITTER ION AND SALT BONDED BODY

Document Type and Number:

Japanese Patent JPS63208522

Kind Code:

A

Abstract:

Amorphous solid formed by lyophilization or cosolvent precipitation of an aqueous solution of 7-[ alpha -(2-aminothiazol-4-yl)- alpha -(Z)-methoximinoacetamido]-3-[(1-methyl-1-pyrrolidinio)-methyl[-3-ceph em-4-carboxylate zwitterion and a salt or mixture of salts from a selected particular group is a broad spectrum antibiotic composition and has better temperature stability at least up to 45 DEG C. than the zwitterion. The salt is one wherein the cation is selected from the group consisting of sodium, lithium, calcium, and magnesium and the anion is selected from the group consisting of chloride, bromide, and iodide. The molar ratio of zwitterion to salt ranges from about 0.5:1 to about 2:l.

Inventors:

MARII AASAA KAPURAN
JIYOSEFU BARAADO BOGAADASU
NAAGESUWARA AARU PAREPU

Application Number:

JP29385587A

Publication Date:

August 30, 1988

Filing Date:

November 20, 1987

Export Citation:

Click for automatic bibliography generation Help

Assignee:

BRISTOL MYERS CO

International Classes:

A61K9/00; A61K9/14; A61K9/19; A61K31/545; A61K31/546; A61K47/02; C07D501/46; (IPC1-7): A61K31/545; C07D501/46

Attorney, Agent or Firm:

Minoru Nakamura (4 outside)

Previous Patent: REMEDY FOR RHEUMATIC ARTHRITIS BY 3,5-DICHLOROMETHOTREXATE

Next Patent: OXYGEN CARRIER