REMEDY FOR RHEUMATIC ARTHRITIS BY 3,5-DICHLOROMETHOTREXATE

Title:

REMEDY FOR RHEUMATIC ARTHRITIS BY 3,5-DICHLOROMETHOTREXATE

Document Type and Number:

Japanese Patent JPS63208521

Kind Code:

A

Abstract:

Joint destruction associated with arthritic disease in warm blooded animals is treated with unexpected safety using 3,5-dichloromethotrexate. The therapeutic index therefor is unexpectedly enhanced through combination therapy using a post administration of leucovorin.

Inventors:

SURESHIYU ESU KERUWARU
ADORUFU II SUROBODA

Application Number:

JP3198688A

Publication Date:

August 30, 1988

Filing Date:

February 16, 1988

Export Citation:

Click for automatic bibliography generation Help

Assignee:

AMERICAN CYANAMID CO

International Classes:

A61K31/505; A61K31/519; A61P29/00; C07D475/08; F16H59/40; F16H59/48; (IPC1-7): A61K31/505; C07D475/08

Attorney, Agent or Firm:

Heikichi Odashima

Previous Patent: BLOOD PLATELET AGGLUTINATION INHIBITOR CONTAINING PYRAZINE DERIVATIVE

Next Patent: FREEZE-DRIED OR SEDIMENTED CEPHALOSPORIN ZWITTER ION AND SALT BONDED BODY